摘要
目的:探讨1H-MRS对高级别胶质瘤与单发转移瘤鉴别诊断的临床应用价值。材料与方法:27例经病理证实或临床证实患者,高级别胶质瘤16例,单发转移瘤11例。采用单体素波谱采集或二维波谱化学位移成像对肿瘤瘤体及瘤周进行波谱采集。数据分析采用STUDENTt检验,对有显著性差异者进行均数比较。结果:高级别胶质瘤与单发转移瘤瘤体CHO/Cr值均升高,二者存在显著性差异;高级别胶质瘤瘤周CHO/Cr值升高。转移瘤瘤周CHO/Cr值无明显升高。NAA/Cr值二者间均无显著性差异。结论:高级别胶质瘤与转移瘤瘤体与瘤周CHO/Cr值存在显著性差异,对二者鉴别有重要意义。
Purpose： To determine wbether ^1H- MRS can be used to differentiate high- grade primary gliomas and solitary metastases on basis of difference in metabolite levels both in the tumor and peritumoral region. Materials and Methods： 27 patients with a solitary brain tttmor （16 gliomas,11 metastases） underwent ^1H- MRS imaging before surgical treatment, stereotaetie biopsy and other therapy. All the patients were evident by patliology or tbe following examination and survey. Spectra from the erdaeneing tumor, tbe peritumoral region and normal brain was obtained feom the. two - dimensional spectroscopic MR imaging the student t test was used to determine ff there was significant statistical differece in metabolic ratios between high - grade gliomas and metastases. Results： The ratio CHO/Cr of tumors was elevated in gliomas and metastases, the difference was significant （P 〈 0.05）. The ratio for choline to ereatine was elevated intbe peritumoral region of gliomas but not in metastases. While the ratio of NAA/Cr in the peritumoral region of gliomas and metastases was not statistical significant （P 〉 0.05）. Conclusion： Tbe ratios CHO/Cr in tumor and peritumoral region of high - grade gliomas and metastases have significant statistical differece.
出处
《现代医用影像学》
2007年第3期106-108,共3页
Modern Medical Imageology
