摘要
阿尔茨海默病(AD)是一种常见的老年神经变性疾病,病因十分复杂。目前多数学者认为:β-淀粉样蛋白沉积使得神经胶质细胞活化引起脑内慢性炎症反应可能是AD发病的核心病理机制之一。在AD炎症过程中,渉及到诸多细胞如小胶质细胞、星形胶质细胞及神经元参与,小胶质细胞则是其最主要的炎症细胞,小胶质细胞被β-淀粉样蛋白(Aβ)激活,产生大量致炎性细胞因子和神经元毒性介质,从而诱发脑内炎症反应,导致神经元损伤、死亡。Aβ的持续存在,小胶质细胞被持续激活,形成炎症发生和持续的恶性循环,最后导致AD的发生发展。
Alzheimer＇ s disease （AD） is the most common neurodegeneration disease of old age, the cause of which is very complicated. At present, most of scholars think that the deposit of β-amyloid make the activation of neuroglial cells, which trigger the chronic inflammatory reactivity in AD brain. A lot of cells such as microglia, astrocyte and neuron are involved in the process of AD, microglial cells are the most important cells in AD brain. Microglia can be activated by β-amyloid protein. This activation can produce further release of pro-inflammatory cytokines and toxic mediators that might induce inflammatory responses in AD brain and might contribute to neuronal injury and death. Aβ and activated microglia persist and thus initiate a vicious circle of inflammatory processes, which finally leads to the development and progression of AD.
出处
《国际病理科学与临床杂志》
CAS
2007年第4期332-335,共4页
Journal of International Pathology and Clinical Medicine
基金
意大利维罗纳大学医学院形态学与生物医学系和中南大学湘雅医学院人体解剖学与神经生物学系合作项目
意大利卫生部和欧盟委员会基金支助课题(QLK6-CT-2002-02258)~~
