摘要
目的观察新生儿缺血缺氧性脑病(HIE)血浆和脑脊液中血管内皮生长因子(Vascular endothelial growthfactor,VEGF)与神经元特异性烯醇化酶(Neuron-specific enolase NSE)含量的动态变化,探索VEGF与HIE早期诊断、预后判断及有关机理的临床相关性。方法选择确诊HIE足月新生儿38例(轻度15例,中度12例,重度11例)作为观察组,12例无神经系统疾病的足月新生儿为对照组;分别于生后24h、7、10天测血浆VEGF和NSE,于生后24h测脑脊液VEGF和NSE,分析VEGF与NSE、疾病程度相关性及意义。结果观察组VEGF与NSE在生后24h即升高,与对照组比较有显著差异(P<0.01);以后逐渐下降,与生后7天比较有显著差异(P<0.05);VEGF与NSE、疾病程度有相关性。结论血管内皮生长因子(VEGF)可能作为新生儿缺血缺氧性脑病(HIE)诊断、疾病严重程度和预后判断的一种重要指标。
Objective： To observe the dynamic changes of vascular endothelial growth factor （VEGF） and neuron -specific enolase （NSE） in eerebrospinal fluid and plasma with hypoxie - isehemie eneephalopathy and investigate early diagnosis, prognostic estimation as well as mechanism of clinic correlation . Methods： 38 newborns with HIE were chosen as experimental group （15eases were mild, 12 moderate, 11 severe）. 13 neonates without nervous system diseases were used as controls. They were examined plasma VEGF and NSE in 24hours, 7days, lOdays after birth respectively. VEGF and NSE of eerebrospinal fluid were measured in 24bours after birth. The value and correlation among VEGF, NSE and grade of HIE were analyzed. Results： VEGF and NSE in the experimental group in 24hours after birth were higher than ones in the controls immediately （ P 〈0.01 ）, and then descended. When they were born after 7days, VEGF and NSE in the experimental group comparing with ones in the controls had significant difference （ P 〈0. 05）. It had a correlation among VEGF and NSE, gade of HIE. Conclusion： VEGF may be used as the significant index in the diagnosis, prognostic estimation and grade of HIE.
出处
《中国优生与遗传杂志》
2007年第9期27-29,共3页
Chinese Journal of Birth Health & Heredity
基金
深圳市医疗卫生系统2005年科技计划项目
关键词
新生儿缺血缺氧性脑病
血管内皮生长因子
神经元特异性烯醇化酶
Neonate with hypoxie- isehemie eneephalopathy
Vascular endothelial growth factor （VEGF）
Neuron- specific enolase （NSE）
