摘要
综述了吴茱萸次碱的药理作用及其相关机制:吴茱萸次碱对心脏有正性肌力、正性变时作用和心脏保护作用,这与其促进降钙素基因相关肽释放有关;吴茱萸次碱有扩血管和降压作用,其机制主要涉及内皮细胞Ca2+-NO-cGMP途径和降钙素基因相关肽的释放;吴茱萸次碱能松弛肛门内括约肌,抑制胃肠运动,对应激性溃疡和溃疡性结肠炎也有治疗作用;吴茱萸次碱对脑缺血再灌注损伤有保护作用,这与其增加降钙素基因相关肽浓度有关;吴茱萸次碱能抑制血小板聚集和动脉血栓形成;此外,吴茱萸次碱还有抗炎镇痛、抗肿瘤等药理作用。
This paper summarizes the pharmacologic action of mtacarpinc and the related mechanism. Rutacarpinc has positive inotropic and chronotropic effect, and cardioprotective effect, these effects are associated with the stimulation of the release of CGRP. Rutacarpine has vasorelaxing effect and hypotensive effect that are mainly related to Ca^2＋ - NO - cGMP pathway of endothelial cells and the release of CGRP. Rutacarpine can relax the internal sphincter muscle of anus and can depress the gastrointestinal motility, it has therapeutic effects on stress ulcer and colitis gravis. Rutacarpine has protective effect on ischemical reperfusion injury of brain, which is related to the increase of the concentration of CGRP. Rutacarpine has inhibitory effects on platelet aggregation and arterial thrombosis. Rutacarpine also has anti - inflammatory effect, Anti - tumor effect, and so on.
出处
《中华中医药学刊》
CAS
2007年第9期1857-1859,共3页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省中医药卫生科技计划项目(2005-123)
关键词
吴茱萸次碱
药理作用
降钙素基因相关肽
rutacarpine
pharmacologic
action calcitonin gene - related peptide
