摘要
目的:考察伊曲康唑(商品名斯皮仁诺)在皮肤真菌性疾病治疗剂量下的药物安全性。方法:分别测定治疗剂量、中毒剂量、致死剂量组小鼠在用药一段时间后的肝肾功能,并进行组织病理学检查。结果:2.5%的小鼠出现了轻度的肝酶升高,6.25%的小鼠病理检查肝组织出现了轻度的脂肪变性,且结果异常的小鼠绝大多数发生于中毒剂量及致死剂量组,肾脏无明显改变。结论:治疗剂量的伊曲康唑可以应用于皮肤真菌性疾病的治疗,安全性较高,无明显肝肾损伤。
Objective To study the security of Itraconazole（commercial name is Sporanox） in the treatment of fungal disease under treatment dose.Method Hepatic and renal functions,and tissue biopsy were measured in rats with therapeutic,toxic and lethiferous dose treatment after a period of time.Results 2.5% of rats got slight hepatic enzymes increase and 6.25% got slight fat degeneration in hepatic tissue specimens.Most of the rats with abnormal results were in toxic and lethiferous groups,and there was increasing tendency with the increase of dose.There were no changes in renal function and tissue biopsy.Conclusion Itraconazole of therapeutic dose can be used in fungal disease with high security,and without obvious hepatic and renal damage.
出处
《吉林医学》
CAS
2007年第5期584-586,共3页
Jilin Medical Journal
基金
中华医学会西安杨森基金资助项目
