摘要
目的研究丙戊酸钠(VPA)对托吡酯(TPM)神经保护作用的影响。方法将3～4周龄雄性Wistar大鼠48只,随机均分为4组。A组为阴性对照组,B为阳性对照组。C、D组于戊四氮(PTZ)腹腔注射后予TPM40mg/kg、TPM40mg/kg+VPA200mg/kg;A、B组予等量蒸馏水。连续用药2个月,观察血清神经元特异性烯醇化酶(NSE)及其病理改变。结果C组NSE水平与B组差异显著,D组与B组无差异。C组较D组海马组织神经元退行性变和胶质细胞增生程度减轻。结论TPM联合VPA将削弱癫大鼠神经保护作用。
Objective To study the influence of valproate sodium（VPA）on neuroprotective effects of topiramate（TPM）.Methods For-ty-eight 3-4 week-old male Wistar rats were randomly divided into 4 groups of 12 rats each.Group A was negative control rats,and groups B-D were rat model of epilepsy,induced by pentylenetetrazol（PTZ）.The rats in 2 experimental groups were adminstered intragastrically with TPM 40 mg/kg and TPM 40 mg/kg＋ VPA 200 mg/kg;2 control groups（groups A and B）with the equal amount of distilled water administration.After 2-month administration,changes of the behavior,levels of serum neuron-specific enolase（NSE）and the pathological in hippocampus were examined.Results The level of NSE in the group of TPM were significantly lower than that in masculine group,but no difference between masculine group and the TPM plus VPA.The pathological change in hippocampus were abatement in the group of TPM.Conclusion TPM plus high dosage of VPA will impaire the neuroprotective effects of TPM.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2007年第17期1338-1339,1357,共3页
Journal of Applied Clinical Pediatrics
关键词
丙戊酸钠
托吡酯
神经保护
癫痫
valproate sodium
topiramate
neuroprotective
epilepsy
