摘要
目的:探讨大柴胡汤加减方(简称中药)结合西药对初发2型糖尿病患者治疗作用及胰岛β细胞功能的改善作用。方法:将72例初发2型糖尿病患者随机分为3组,分别用口服降糖药物(瑞格列奈)(A组23例)、胰岛素组(B组25例)及胰岛素加中药(C组24例)联合治疗,观察治疗前后血糖、糖化血红蛋白及胰岛β细胞功能的变化。结果:A组患者胰岛β细胞功能的受损没有得到改善,C肽分泌峰值仍然较低而且后延,而B组和C组患者口服葡萄糖耐量试验后的C肽分泌峰均有提前,表明B、C两组患者胰岛β细胞功能均有不同程度改善和恢复,但C组患者的效果最好。结论:中药具有一定程度的降低血糖和保护胰岛β细胞功能的作用,与胰岛素联用具有协同和增效作用。对于初发2型糖尿病患者,应尽早采用胰岛素或胰岛素与中药联合治疗。
Objective： To study the effect of integrative Chinese and Western medicine （ICWM） on improvement of the islet β cell function in treating patients with latent autoimmune diabetes mellitus in 2Diabetes. Methods： Sixty-four patients of 2Diabetes were randomly divided into 3 groups （20 in A, 23 in B and 21 in C） ,they were treated respectively with sulfonylurea, insulin and combination of insulin and Chinese medicine, The changes before and after treatment in blood glucose, glycohemoglobin and isleβ cell function were observed. Results： After treatment, the damaged isletβcell function in Group A was not improved, the secrete peak value of C2peptide was still low and delayed in Group A, but in Group B and C, it shifted earlier, suggesting that a certain degree of improvement and recovery of isletβcell function. The improving effect in Group C was better. Conclusion ： Chinese herbal medicine had effect in lowering blood glucose and improving isleβcell function in patients with diabetes mellitus, and showed a synergistic and enhancing action when combined use with insulin. Early treatment of insulin or combination of insulin and Chinese medicine should be applied to patients with 2Diabetes.
出处
《中国医药导刊》
2007年第4期328-330,共3页
Chinese Journal of Medicinal Guide
