摘要
以刺激海马脑片ＣＡ３区ｓｃｈａｆｅｒ侧支诱发ＣＡ１区的电位变化为指标，观察脑片在缺氧、复氧过程中群锋电位（ＰＳ）的变化，研究毛冬青甲素（ＩＡ）对其影响及谷氨酸（Ｇｌｕ）在其中所起的作用。实验结果表明，ＩＡ能明显延长ＰＳ幅值在缺氧时开始减小和消失的时间；明显降低缺氧损伤电位出现率和提高复氧后ＰＳ的恢复率；明显对抗Ｇｌｕ对ＰＳ幅值的抑制性影响。提示ＩＡ对大鼠海马脑片缺氧损伤具有明显保护作用，其作用机制与对抗Ｇｌｕ的神经毒性作用有密切关系。
The effect of Ilexonin A (IA) on neurons of rat hippocampus in hypoxic injury was studied by observing the changes of the amplitude of population spike (PS) of pyramidal cells through stimulating the cells in the CA 1 area of the hippocampus. The results showed that IA can prolong the starting decreasing time and disappearing time of the amplitude of PS, decrease the appearing rate of hypoxic injury potential, increase the recovery rate after reoxgenation, and counteract the glutamate inhibition to the amplitude of PS significantly. It is revealed that IA possesses a protective effect on neurons in hypoxic injury and its mechanism is closely linked to the resistance against the glutamate neurotoxicity.
出处
《广州中医药大学学报》
CAS
1997年第2期97-101,共5页
Journal of Guangzhou University of Traditional Chinese Medicine
关键词
毛冬青甲素
药理学
脑缺氧
中医药疗法
海马
ILEXONIN A/pharm. CEREBRAL ANOXIA/TCM ther. HIPPOCAMPUS /drug eff.
