摘要
目的:考察几种冻干保护剂对齐墩果酸纳米悬浮液冻干过程中的保护作用,筛选出最佳配方。方法:通过测定齐墩果酸纳米粒冻干前后的粒径变化,来评价保护效果和优选配方。结果:10%的蔗糖能对齐墩果酸纳米粒起到最佳的保护效果,样品的粒径为236.3nm(冻干前211.2nm),多分散系数0.242比冻干前(0.180)有很少的增加。结论:合适浓度的冻干保护剂在合理的冷冻条件下可以获得最佳的纳米悬浮液的冻干粉。
Objective： Several cryoprotectants were employed to study the protective effect on the freeze-drying process of the oleanolic acid-loaded nanosuspensions （OLA-LS） in order to select the optimum formulation. Method： The protective effect was evaluated by measuring the mean particle size of samples before and after freeze-drying process. Result： Sucrose with the concentration of 10% was selected as the optimum cryoprotectant. The average size of excellent sample was 236. 3 nm （versus 211.2 nm of fresh one）, and a much higher polydispersity index of 0. 242 （ versus 0. 180）. Conclusion： The optimum lyophilized powder could be obtained with suitable type of cryoprotectant with appropriate concentration and proper freeze-drying conditions.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2007年第18期1874-1876,共3页
China Journal of Chinese Materia Medica
关键词
纳米悬浮液
冷冻干燥
冻干粉
nanosuspensions
cryoprotectant
lyophilized powder
