摘要
目的:对72例药物性肝病患者进行了分析,以提高临床医生对该病的认识,并给予及时有效的治疗。方法:采用回顾性调查方法对我院收治的72例药物性肝病患者用药史、临床表现、实验室检查、治疗转归进行分析。结果:引起药物性肝病的药物中,抗结核药22.2%、抗菌药19.4%、中药13.9%、抗甲亢药12.5%、解热镇痛药9.7%、降脂药6.9%、免疫抑制剂5.6%、其他9.8%。临床分型:72例中肝细胞损伤型62.5%,胆汁淤积型22.2%,混合型15.3%。54例病人肝功能在停药后1个月恢复正常,10例(13.9%)病人肝功能在2个月恢复正常,无死亡病例。结论:引起药物性肝病的常见药物为抗结核药,抗菌药及中药,停用相关药物后,预后良好。
Objective：To reviewed retrospectively 72 patients with drug-induced liver disease（DIMD）,so as to improve the knowledge,diagnosis and treatment of the diseases.Methods：The clinical data of 72 patients fulfilled the diagnostic criteria including drug using history,clinic features,Lab examination,therapy and prognosis were reviewed and analyzed.Results：The etiological agents were identified as following drugs,antiturbercular agents 22.2%（16 cases）,antibiotics 19.4%（14 cases）,chinese herbal 21%（10 cases）,endocrinal drugs 12.5%（9 cases）,analgesic-antipyretic drugs 9.7%（7 cases）,cholesterol-lowering drugs,immunosuppressive agents 5.6%（4 cases） and miscellaneous 9.8%（7 cases）.Clinical types： There were 45 cases（62.5%）of acute hepatitis,16 cases（22.2） of acute sholestatic type and 11cases（15.3%） of mixed type.Liver function test of 54 patients（75%） recovered normal within 1 month and 10 cases within 2 months after withdrawing the drugs,no patient died.Conclusion：Drugs antiturbercular agents,analgesic-antipyretic drugs and Chinese herbal are common etiological agents of DILD.Most patients had a good prognosis after withdrawing the relavent drugs.
出处
《实用临床医学（江西）》
CAS
2007年第7期23-24,26,共3页
Practical Clinical Medicine
关键词
药物性肝病
诊断
治疗
drug-induced liver disease
diagnosis
therapy
