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树突状细胞和造血干细胞移植的研究进展 被引量：1

Advance in the research of dendritic cells and hematopoietic stem cell transplantation
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摘要 树突状细胞（DC）是功能最强的抗原递呈细胞（APC），在移植免疫中，DC启动免疫排斥还是维持免疫耐受取决它们的起源以及成熟状态，成熟DC启动免疫排斥及移植物抗宿主病（GVHD）反应，未成熟（iDC）及淋巴样DC诱导免疫耐受。造血干细胞移植（HSCT）中，可以通过调控不同来源、不同分化状态的DC来预防和治疗移植物抗宿主病（GVHD），促进造血干细胞的植入。 Dendritic cells （DCs） are the most potent antigen presenting cells. In transplantation immunity , whether DCs induce rejection or tolerance depends on the source and maturation of DCs. Mature DCs are able to initiate rejection response and graft versus host disease （ GVHD）, while immature DCs or plasmacytoid DCs induce immunity tolerance. In hematopoietic stem cell transplantation（ HSCT）, different originated and differentiated DCs can be modulated to prevent and cure GVHD, and to promote engraftment of hematopoietic stem cells.
作者 汪健 王保龙
机构地区 安徽医科大学附属省立医院输血科
出处 《国际免疫学杂志》 CAS 2007年第5期319-323,共5页 International Journal of Immunology
基金 安徽省高等学校省级科研重点项目（KJ20070A31）
关键词 树突状细胞 造血干细胞移植 移植物抗宿主病 免疫耐受 Dendritic cell Hematopoietic stem cell transplantation Graft versus host disease Immune tolerance
分类号 R [医药卫生]
  • 相关文献

参考文献20

  • 1Pihusch M, Boeck S, Hamann M, et al. Peripheral dendritic cell chimerism in allogeneic hematopoietic stem cell recipients. Transplantation,2005,80 ( 6 ) : 843-849.
  • 2Boeck S, Hamann M, Pihusch V, et al. Kinetics of dendritic cell chimerism and T cell chimerism in allogeneic hematopoietic stem cell recipients. Bone Marrow Transplant, 2006,37 ( 1 ) :57-64.
  • 3Perruche S, Marandin A, Kleinclauss F, et al. Association of mixed hematopoietic chimerism with elevated circulating autoantibodies and chronic graft-versus-host disease occurrence. Transplantation, 2006, 81 (4) :573-582.
  • 4Naranjo GM, Fernandez MA, Bofill M,et al. Primary alloproliferative TH1 response induced by immature plasmacytoid dendritic cellsin collaboration with mMyeloid DCs. Am J Transplantation, 2005,5 ( 12 ) : 2838-2848.
  • 5Ikeda K, Shichishima T, Teshima T, et al. Complete donor chimaerism of Langerhans cells in lymph node early after allogeneic bone marrow transplantation. Eur J Haematol,2006, 76(2 ) :261-264.
  • 6Mohty M, Blaise D, Faucher C, et al. Inflammatory cytokines and acute graft-versus-host disease after reduced-intensity conditioning allogeneic stern cell transplantation. Blood, 2005,106 ( 13 ) :4407-4411.
  • 7Vakkila J, Thomson AW, Hovi L, et al. Circulating dendritic cell subset levels after allogeneic stem cell transplantation in children correlate with time post transplant and severity of acute graft-versus-host disease. Bone Marrow Transplant, 2005,35 (5) :501-507.
  • 8Moyer JS, Maine G, Mule JJ. Early vaccination with tumor-lysatepulsed dendritic cells after allogeneic bone marrow transplantation has antitumor effects. Biol Blood Marrow Transplant, 2006 , 12 ( 10 ) : 1010-1019.
  • 9厉倩,曹雪涛（审校者）.树突状细胞与免疫负向调控[J].国际免疫学杂志,2006,29(1):48-51. 被引量：9
  • 10Rutella S, Danese S, Leone G. Tolerogenic dendritic cells: cytokine modulation comes of age. Blood, 2006 , 108(5 ) : 1435-1440.

二级参考文献22

  • 1Gallegos AM, Bevan MJ. Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J Exp Med,2004,200(8) :1039-1049.
  • 2Jonuleit II, Schmitt E, Schuler G, et al. Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med, 2000,192(9) : 1213-1222.
  • 3Munn DH, Sharma MD, Iee JR, et al. Potential regulatory function of human dendritic cells expressing indoleamine 2, 3-dioxygenase. Science,2002,297(5588) : 1867-1870.
  • 4Wakkach A, Fournier N, Brun V, et al. Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo. Immunity,2003,18(5) :605-617.
  • 5Zhang M, Tang H, Guo Z, et al. Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells. Nat Immunol, 2004,5(11) : 1124-1133.
  • 6Martin P, Del Hoyo GM, Anjuere F, et al. Characterization of a new subpopulation of mouse CD8alphs + B220 + dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential. Blood,2002,100(2) :383-390.
  • 7de Heer H J, Hammad H, Soullie T, et al. Essential role of lung plasmacytoid dendritic ceils in preventing asthmatic reactions to harmless inhaled antigen. J Exp Med,2004,200(1) :89-98.
  • 8Uyttenhove C, Pilotte L, Theate I, et al. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Nat Med,2003,9(10) : 1269-1274.
  • 9Mellor AL, Baban B, Chandler P, et al. Cutting edge: induced indoleamine 2, 3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion. J Immunol, 2003,171(4) : 1652-1655.
  • 10Curiel TJ, Wei S, Dong H, et al. Blockade of B7-H1 improves myeloid dendritic cel-mediated antitumor immunity. Nat Med, 2003,9 (5):562-567.

共引文献8

同被引文献20

  • 1胡珏,肖波,杨欢,李水仙,黄颉,李静,周文斌.树突状细胞负载Tα146-162对实验性自身免疫性重症肌无力的治疗作用[J].中华微生物学和免疫学杂志,2006,26(4):308-311. 被引量：4
  • 2Katoh N,Soga F,Nara T, et al. Effect of serotonin on the differentiation of human monocytes into dendritic cells[J]. Clin Exp Immunol,2006,146(2):354-361.
  • 3Duan RS,Adikari SB, Huang YM,et al. Protective potential of experimental autoimmune myasthenia gravis in Lewis rats by IL-10-modified dendritic cells [J]. Neurobiol Dis,2004,16(2) :461-467.
  • 4Rutella S, Danese S, Leone G. Tolerogenic dendritic cells:eytokine modulation conies of age [J].Blood, 2006,108(5) : 1435-1440.
  • 5Xiao BG, Zhu WH, Lu CZ. The presence of GM-CSF and IL-4 interferes with effect of TGF-betal on antigen presenting cells in patients with multiple sclerosis and in rats with experimental autoimmune encephalomyelitis[J]. Cell Immunol, 2007,249 (1) : 30-36.
  • 6Taher YA,van Esch BC, Hofman GA, et al. 1{ alpha} 25-Dihydroxyvitamin D3 Potentiates the Beneficial Effects of Allergen Immunotherapy in a Mouse Model of Allergic Asthma:Role for IL- 10 and TGF- { beta } [J]. J Immunol,2008,180(8) :5211-5221.
  • 7Spisek R, Gasova Z, Bartunkova J. Maturation state of dendritic cells during the extracorporeal photopheresis and its relevance for the treatment of chronic graftversus-host disease[J]. Transfusion, 2006,46 ( 1 ):55- 65.
  • 8Li M, Zhang X, Zheng X, et al. Immune Modulation and Tolerance induction by RelB-sileneed Dendritic cells through RNA interference[J]. J Immunol, 2007, 178(9) :5480-5487.
  • 9DeJong EC, Smits HH, KaPSenberg ML, et al. Dendritic cell-mediated T cell polarization[J]. Springer Semin Immun,2005,26(3) :289-307.
  • 10de Faudeur G, de Trez C, Muraille E,et al. Normal development and function of dendritic cells in mice lacking IDO- 1 expression[J]. Immunol Lett, 2008,118 (1):21-29.

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国际免疫学杂志
2007年 第5期

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