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核因子кB与2型糖尿病关系的研究进展 被引量：3

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摘要 近年来研究显示2型糖尿病是一种与炎症有关的疾病,炎症可以导致胰岛素抵抗和动脉粥样硬化。此外炎症尚参与胰岛β细胞损伤。NF-кB是一种重要的转录调节因子,其在细胞信号传递和基因的诱导表达过程中起重要作用。本文就NF-кB与2型糖尿病的关系做简要介绍。
作者 何媛媛 李素梅 叶山东
机构地区 安徽医科大学附属省立医院内分泌科
出处 《国外医学（老年医学分册）》 2007年第5期220-225,共6页 Foreign Medical Sciences(Geriatrics)
关键词 NF—κB 胰岛素抵抗 2型糖尿病 动脉粥样硬化
分类号 R587.1 [医药卫生—内分泌]
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参考文献29

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同被引文献38

  • 1林振和,陈垦.核因子-κB信号转导途径的调节研究进展[J].国外医学（免疫学分册）,2004,27(4):234-238. 被引量：26
  • 2罗军,靳风烁.核转录因子-κB与免疫应答[J].国外医学（免疫学分册）,2004,27(5):294-297. 被引量：7
  • 3蒋叶,余书勤.核转录因子-κB信号通路在内毒素致急性肺损伤中的作用[J].中国急救医学,2004,24(12):902-904. 被引量：14
  • 4王燕燕,王杨天,狄红杰,卢斌,赵明.糖尿病大鼠坐骨神经的核因子-κB表达及干预[J].江苏医药,2006,32(7):645-647. 被引量：1
  • 5Tuttle KR. Linking metabolism and immunology : diabetic nephropathy is an inflammatory disease. J Am Soc Nephrol, 2005,16(6):1537-1538.
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  • 7Wolf G, Ritz E. Combination therapy with ACE inhibitors and angiotensin II receptor blockers to halt progression of chronic renal disease:Pathophysiology and indications. Kidney Int,2005,67: 799-812.
  • 8Ruggenenti P. Angiotensin-converting enzyme inhibition and angiotensin 11 antagonism in nondiabetic chronic nephropathies. Semin Nephrol, 2004,24(2):158-167.
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  • 10Manna SK,Arrarwal BB. Immunosuppressive leflunomide met abolite (A771726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression. J immunol, 1999,162 (4): 2095 -2102.

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国外医学（老年医学分册）
2007年 第5期

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