摘要
目的了解骨质疏松症与焦虑、抑郁状态的相关性。方法选取来我院门诊就诊和住院的绝经后骨质疏松患者74例和非骨质疏松患者76例,采用综合性医院焦虑抑郁量表和健康状况调查问卷对其焦虑、抑郁状态及生活质量进行评估,同时采用RIA方法测定雌二醇、睾酮、孕酮、促卵泡素和促黄体生成素水平。结果骨质疏松组患者血清E2水平较对照组降低,差异有显著性(P=0.020),而骨质疏松组FSH较对照组有所升高,差异有显著性(P=0.024),骨质疏松患者的焦虑分、抑郁分均显著高于对照组,差异均有显著性(P<0.01)。骨质疏松患者的生活质量显著低于对照组,8个纬度分值均显著高于对照组,差异均有显著性(P<0.01)。结论焦虑、抑郁状态也是绝经后骨质疏松的危险因素,对这部分患者进行有针对性的心理咨询和干预治疗也是非常必要的。
Objective To investigate the effect of anxiety and depression on patients with osteoporosis. Methods 74 osteoporosis patients and 76 healthy women in patient and out-patient department were assessed with the shortform-36 health survey（SF-36） as well as the hospital anxiety and depression scale（HAD）. RIA method was used to observe the levels of Estradiol, Testosterone, Progesterone, Follicle-stimulating hormone and Luteinizing hormone. Results The levels of serum E2 in the osteoporosis patients were significantly lower than the control group（ P = 0.020）. Compared with the control group, the levels of serum FSH in osteoporosis patients were increased （ P = 0.024）. Both the prevalence of the negative emotions and HADs score were significantly higher in osteoporosis patients than the control group （ P 〈 0.01 ）. The quality of life in osteoporosis patients was much poorer than that of the control group, which could be shown from the deceased scroes 8 related aspects in the investigating group（ P 〈 0.01 ）. Conclusions Anxiety and depression are also the most important risk factors to post-menopause osteoporosis. Effective psychological consultation and treatment are necessary for those osteoporosis patients.
出处
《中国骨质疏松杂志》
CAS
CSCD
2007年第9期642-644,共3页
Chinese Journal of Osteoporosis
关键词
骨质疏松症
焦虑
抑郁
生活质量
Osteoporosis
Anxiety
Depression
The quality of life
