摘要
【目的】研究慢性肝病及肝癌组织中Bcl-2蛋白的表达及其意义。【方法】对20例慢性肝病[7例慢性迁延性肝炎(CPH),8例慢性活动性肝炎(CAH),5例肝炎后肝硬化(LC)]和39例原发性肝癌(肝细胞肝癌34例,胆管细胞性肝癌5例)组织中Bcl-2蛋白进行ABC免疫组化染色。【结果】正常肝组织中Bcl-2蛋白表达为阴性,慢性肝病组织中阳性表达率为10%,原发性肝癌组织中的阳性表达率为43.5%,且Bcl-2蛋白表达与肝癌的病理类型、分化程度有关。【结论】Bcl-2蛋白在肝癌组织中有较高的阳性表达率,可能与肝癌的发生有关,并对肝癌恶性程度及预后判断可能有意义。
To explore the expression and biological significance of Bcl-2 oncoprotein in Chronic Liver Diseases and Hepatocarcinomas. [Methods]The Expression of Bcl-2 Oncoprotein was investigated by Avidin-Biotin Complex（ABC） immunohistochemical method in 20 eases of chronic liver diseases （included： 7 cases of CPH, 8 eases of CAH and 5 eases of LC） and 39 cases of primary hepatocarcinoma（PHC）. [Results] The expression of Bcl-2 oncoprotein was negative in normal liver tissue. The positive rates of Bcl-2 oncoprotein were 10 % in chronic liver diseases. The positive rates of Bcl-2 oncoprotein were 43.5% in PHC, the close correlationships were found among the expression of Bcl-2 oncoprotein and the pathological types and differentiated degrees of PHC. [Conclusion]The expression of Bcl-2 oncoprotein might be related to the carcinogenesis of PHC and might be significant in reflecting the biological behaviors or prognosis of PHC.
出处
《医学临床研究》
CAS
2007年第9期1501-1503,共3页
Journal of Clinical Research
