摘要
目的探讨土鳖虫溶栓酶的抗凝血和抗血栓作用。方法给药后检测凝血时间、凝血酶原时间、血纤维蛋白原含量、血凝块溶解率。用体内、外血栓形成溶解实验检测抗血栓作用。结果土鳖虫溶栓酶0.25、0.5、1.0 mg/kg能明显延长小鼠凝血时间、大鼠凝血酶原时间,降低大鼠血纤维蛋白原含量,增加血凝块溶解率,延长大鼠颈动脉血栓形成的时间,缩短大鼠体外血栓长度,减轻血栓的湿重及干重。结论土鳖虫溶栓酶具有抗凝血和抗血栓作用。
Objective Methods To study the antithrombotie activity and anfieoagulability of the thrombolytie enzyme from Eupolyphage sinensis Walker（TEESW）. Methods The effects of TEESW on coagulation time, prothrombin time （FF）, the fibfinogen （Fbg） coments were observed. The effects of TEESW on anfithrombus formation were also observed by thrombosis experiment in rats. Results At the dose of 0.2.5,0.5 and 1. 0 mg·kg^-1, it could significantly prolong the coagulation time in mice, PF in rats, decrease the Fbg content in rats, inhibite thrombosis of rats in vivo and in vitro. Conclusion the thrombolytic enzyme from Eupolyphage sinensis Walker possesses antieoagulability and antithrombotie activity.
出处
《中国实验诊断学》
2007年第9期1143-1145,共3页
Chinese Journal of Laboratory Diagnosis
基金
吉林省科技发展计划资助项目(200505102)。
关键词
溶栓酶
土鳖虫
抗血栓
抗凝血
thrombolytic enzyme
eupolyphage sinensis walker
thrombolytic activity
anticoagulability
