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三虎丸对佐剂性关节炎大鼠血清IL-1、TNF-α和PGE_2的影响

Effects of Sanhu Pill on IL-1,TNF-α and PGE_2 in Serum of Rat with Adjuvant-induced Arthritis
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摘要 目的:探讨三虎丸对佐剂性关节炎大鼠模型白细胞介素IL-1、肿瘤坏死因子(TNF-α)、前列腺素E2(PGE2)活性的影响。方法:建立佐剂性关节炎大鼠模型,用放射免疫法检测血清TNF-α和IL-1活性和PGE2的含量。结果:与正常组比较,模型组、益肾蠲痹丸组、三虎丸组TNF-α、IL-1和PGE2的含量均有增高,差异有统计学意义(P<0.01),与模型组比较,益肾蠲痹丸组、三虎丸组TNF-α、IL-1和PGE2的含量均有下降,差异有统计学意义(P<0.01或P<0.05),益肾蠲痹丸组与三虎丸组比较,TNF-α、IL-1和PGE2的含量均有不同程度降低,差异有统计学意义(P<0.05)。结论:三虎丸能控制佐剂性关节炎大鼠血清中的IL-1、TNF-α、PGE2等炎症介质的活性,对类风湿关节炎具有治疗作用。 Objective: To explore the effects of Sanhu Pill on IL - 1, TNF -α and PGE2 in serum of rat with adjuvant - induced arthritis(AA). Methods : The AA model was established. Radio - immunity was used to determine the contents of IL - 1, TNF - αand PGE2. Results : Compared with normal group, all the contents of these targets increased in model group, Yishenjuanbi pill group and Sanhu pill group, the difference had statistical significance ( P 〈 0, 01 ) ; while compared with model group, the contents of these decreased in Yishenjuanbi pill group and Sanhu pill group, the difference had statistical significance ( P 〈 0.01 or P 〈 0.05 ) ; Yishenjuanbi pill group vs Sanhu pill group, the contents of these decreased with different degree, the difference had statistical significance( P 〈 0. 05 ). Conclusion: Sanhu pill can control the activity of IL - 1, TNF - α and PGE2 in serum of rat with AA, with therapeutic effects on rheumatoid arthritis.
出处 《中医药导报》 2007年第9期15-16,共2页 Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金 湖南省卫生厅中医药科研基金课题(02-03LL11)
关键词 三虎丸 佐剂性关节炎 白细胞介素I 肿瘤坏死因子 前列腺素E2 Sanhu Pill Ajuvant - induced arthritis IL - 1 TNF - α PGE2
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