摘要
将红鲫(Carassius auratus)分别暴露于0.25mg.l-1四溴双酚A(TBBPA)和0.05mg.l-1五溴酚(PBP)中6周,采用组织切片的方法,观测红鲫甲状腺滤泡形态结构的变化,并以100mg.l-1高氯酸钠(NaClO4)和0.25mg.l-1氯化镉(CdCl2)作为参照,探讨TBBPA和PBP在体时(in vivo)对鱼类甲状腺可能的致毒机理.结果显示,经TBBPA和PBP暴露后,红鲫甲状腺发生了滤泡上皮增厚、细胞肥大和增生等现象,表明这两种溴化阻燃剂均能造成甲状腺结构的损伤.这与NaClO4所引起的甲状腺滤泡的变化非常相似,而与CdCl2所引起的滤泡上皮变薄刚好相反.由此推测,TBBPA和PBP在鱼体内可能引起甲状腺素水平的降低,进而导致甲状腺滤泡细胞的代偿性增生和肥大.
In present study, freshwater fish Carassius auratus were exposed to 0. 25mg·l^-1 tetrabromobisphenol A （TBBPA）and 0. 05mg·l^-1 pentabromophenol（PBP）singly for 6 weeks for thyroid histology observation. To reveal the toxic mechanism of TBBPA and PBP in vivo, 100 mg·l^-1 sodium perchlorate（NaClO4） and 0. 25 mg·l^-1 cadmium chloride （CdCl2 ） were set as confer. The result showed that TBBPA and PBP could induce the increase of the thyroid epithelial with cell hypertrophy and hyperplasia, which suggest that both brominated flame retardants could damage fish＇ s thyroid structure. These effects were very similar to the changes of fish exposed to NaClO4 while they were contrary to the change of fish exposed to CdCl2, which led to the attenuation of the thyroid epithelial. It was deduced that the aberration of thyroid epithelial mediated by TBBPA and PBP might be due to their binding to transthyretin in fish, thereby decreasing their thyroid hormone levels.
出处
《环境化学》
CAS
CSCD
北大核心
2007年第5期588-592,共5页
Environmental Chemistry
基金
国家自然科学基金(20507007)
长江水环境教育部重点实验室开放基金(YRWEF06003)
上海市城市化过程与生态恢复重点实验室开放基金(UPER0606)资助
关键词
甲状腺干扰物
四溴双酚-A
五溴酚
红鲫
thyroid disrupting chemicals （TDCs）, tetrabromobisphenol A （ TBBPA ）, pentabromophenol （PBP）, Carassius auratus.
