摘要
目的探讨高血压患者长期服用氨氯地平对动脉弹性及左心室肥大的影响。方法观察76例坚持服用氨氯地平治疗36月高血压病患者,分别在治疗前后用动脉弹性功能测定仪检测动脉弹性,用超声心动图检测左心室质量指数。结果治疗后小动脉弹性指数(3.80±2.09mL/Pa)较治疗前(2.60±0.77mL/Pa)显著增加(P<0.01);治疗后左心室质量指数(131.7±24.3g/m2)较治疗前(147.3±26.8g/m2)明显降低(P<0.01)。结论钙通道阻滞剂氨氯地平在平稳降压的同时,能恢复受损的动脉血管弹性,改善血管功能,减轻甚至逆转左心室肥大。
Aim To evaluate the clinical effects of amlodipine on arterial elasticity and left ventricular hypertrophy in elderly hypertensive patients. Methods The arterial elasticity indexes of the hypertensive patients（76 cases） were detected with CVP rofilor DO-2020,and left ventricular mass indexes were measured with ultrasound cardiography before and after long-term （36 months） treatment with amlodipine. Results the blood pressure was controlled to therapeutic aim and maintained stable after 8 weeks treatment with amlodipine. The small artery elasticity index rised significantly than that after 36 months treatment with amlodipine （2.60±0.77 mL/Pa vs 3.80±2.09 mL/Pa, P〈0.01）; and the left ventricular mass indexes reduced dramatically than that after therapy （147.3±26.8 g/m^2 vs 131.7±24.3 g/m^2,P〈0.01）. Conclusion Amlodipine can improve arterial eladticity and vascular function,retard or even reverse left ventricular hypertrophy,while lowering blood pressure stably.
出处
《中国动脉硬化杂志》
CAS
CSCD
2007年第7期503-505,共3页
Chinese Journal of Arteriosclerosis
关键词
内科学
氨氯地平
高血压
动脉弹性
左心室肥大
Amlodipine
Hypertension
Areterioles
Eladticity
Left Ventricular Hypertrophy
