摘要
目的探讨与评价老年高血压患者的生存质量(QOL),为全面评价抗高血压治疗效果提供相应的依据。方法应用SF-36生存质量量表对292例老年高血压患者及300名正常血压老年人进行了同期的横断面调查与比较,并用受试者特征曲线(ROC曲线分析法)确定QOL最佳诊断参考值。此外,对其中适宜抗高血压药物治疗的115例高血压老年患者,采用自身前后对照设计,经1年正规治疗后,分析其QOL与治疗效果之间的关系。结果①老年高血压患者有关生存质量9项指标均较正常血压对照组减低,差异有统计学意义(P<0.0005～0.001);②ROC分析结果,QOL正常诊断值1900分,其敏感度80.0%,特异度70.0%;③115例稳定高血压老年患者经1年治疗后,药物治疗有效率为67.8%,QOL改善率为84.3%。结论老年高血压患者的生存质量显著低于正常血压者;QOL测试有利于对高血压老年患者治疗效果的综合评价。
Objective To explore the quality of lives （QOL） of hypertensive patients and to provide relative evidence to evaluate the effctiveness of antihyperteasive therapy in clinical practice. Methods A cross-sectional study was conducted to investigate 292 old patients with HBP and 300 normotensives using SF-36 short form of quality of Life in the community. The cutoff point score of QOL was decided by receiver operating characteristic （ROC） curve analysis.There were 115 old patients with BP≥160/95 mmHg who had been treated by antihyperteasive drugs for 1 year. Before and after the treatment, their QOL was measured and evaluated, and the relationship between the changes of QOL and anfihyperteasive effects was evaluated. Results The 9 domains of quality of life were significantly lower in the old hypertensive group than that in the normotensive group （ P 〈 0.0005 - 0.001 ） .A cutoff paint of QOL was decided using ROC analysis in which the 1900 score was the best one for diagnostic QOL with the sensitivity of 80% and a aspecificity of 70% .The target rate of the antihyperteasive care and the improved rate of QOL for 115 old patients with HBP were 67.8% and 84.3% separately after a 1 year treatment. Conclusion The QOL of these hypertensives was signicantly lower than that in the normotensives in the study. The measurement of QOL was useful to evaluate the antihyperteasive effectiveness for the old folks in clinical practice.
出处
《中国自然医学杂志》
CAS
2007年第4期302-305,共4页
Chinese Journal of Natural Medicine
基金
深圳市科技计划项目(200603290)
深圳市福田区科技局立项课题(FT200650)
