摘要
目的探讨痛泻二草方对肝郁脾虚型溃疡性结肠炎(UC)模型大鼠肠黏膜屏障损伤的影响。方法采用综合法成功建立肝郁脾虚型UC大鼠模型并给药治疗后,对比各组大鼠肠黏膜病理、充血积分、组织损伤评分及肠黏膜一氧化氮(NO)、一氧化氮合酶(NOS)检测结果。结果痛泻二草方可显著降低UC模型大鼠肠黏膜充血积分、组织损伤评分及NO、NOS的含量(P<0.05或P<0.01),病理切片结果表明痛泻二草方可减轻结肠黏膜损伤。结论痛泻二草方具有减轻UC模型大鼠炎性反应、减缓充血水肿和肠黏膜损害而促进溃疡愈合的作用。
Objective To study effects of Tongxie Ercao Fang（TXECF） on barrier loss of intestinal mucosa in rats with ulcerative colitis（UC） of stagnation of liver-qi and deficiency of the spleen. Methods UC models were established by the composite method. After the rats were treated, contrasted pathologic change, congestive integral, score of tissue damage and the contents of NO and NOS in intestinal mucosa of rats in every group. Results Compared with model group,TXECF could significantly decrease congestive integral, score of tissue damage and the contents of NO and NOS （P 〈 0. 05 or P 〈 0.01 ）, and alleviate damag sa. Conclusion It was suggested that TXECF had the functions of reducing inflammatory and edema, damage of intestinal mucosa in rats with UC. e of intestinal mucoreaction, hyperemia
出处
《甘肃中医学院学报》
2007年第5期3-7,共5页
Journal of Gansu College of Traditional Chinese Medicine
基金
甘肃省自然科学基金资助项目(ZS031-A25-076-E)
甘肃省教育厅基金资助项目(034B-05)
关键词
痛泻二草方
溃疡性结肠炎
充血积分
组织损伤评分
NO
NOS
Tongxie Ercao Fang （TXECF）
ulcerative colitis
congestive integral
score of tissue damage
NO
NOS
