摘要
噻吩甲醛经与硝基甲烷缩合、还原、与甲醛缩合、环合制得主环４，５，６，７－四氢噻吩并［３，２－Ｃ］吡啶，然后用２－氯氯苄进行Ｎ－烃化、成盐制得盐酸噻氯匹定，总收率３８．６％。
The new platelet aggregation inhibitor ticlopidine hydrochloride was synthesized from 2 thiophencarboxaldehyde through condensation with nitromethane,followed by reduction to give 2 (2 thienyl)ethylamine,which was reacted with formaldhyde,subsequent annulation and final condensation with 2 chlorobenzyl chloride.The reaction conditions were modified to give 38.6% overall yield.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1997年第5期197-199,共3页
Chinese Journal of Pharmaceuticals
关键词
血小板聚集抑制
盐酸噻氯匹定
四氢噻吩并
吡啶
platelet aggregation inhibitor,ticlopidne hydrochloride,4,5,6,7 tetrahydrothienopyridine,synthesis
