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急慢性白血病患者血清EPO与TPO水平的动态测定及临床意义 被引量:7

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摘要 目的揭示急慢性白血病在化疗前后血清红细胞生成素(EPO)、血小板生成素(TPO)水平与血红蛋白、红细胞数量、血小板数量的关系及其意义。方法采用夹心酶联免疫法测定26例急性白血病(AL)、15例慢性白血病(CL)、28例健康人血清EPO,TPO,同时测红细胞数、血红蛋白数、血小板数。结果急慢性白血病化疗前后血清EPO,TPO水平高于对照组。AL化疗前后EPO与Hb、RBC,TPO与Plt间呈负相关,而CL呈不相关;AL,CL化疗前后TPO与EPO呈正相关。AL化疗前EPO,TPO水平高于AL化疗后,CL化疗前后EPO,TPO水平差异无显著性。结论AL,CL在化疗前后EPO,TPO水平高于对照组,使用rhEPO,rhTPO治疗贫血、血小板减少仍可能有效。推测AL在化疗前、CL在化疗后使用rhEPO,rhTPO可能改善贫血、血小板减少更有效。
出处 《广东医学》 CAS CSCD 北大核心 2007年第10期1658-1660,共3页 Guangdong Medical Journal
基金 遵义市科技局资助项目(编号:2003-D-10)
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