摘要
目的观察多西紫杉醇联合5-氟尿嘧啶、亚叶酸钙及草酸铂治疗胃癌肝转移的疗效及毒副反应。方法多西紫杉醇50mg/m2,d1,草酸铂100mg/m2,d1,5-Fu750mg/(m2.d)持续静脉滴注48h,d1～2,CF200mg,d1～3,每2周重复。完成3周期后评价疗效。结果全组24例患者,治疗后CR2例,PR12例,RR(CR+PR)为58.3%。中位生存时间(MST)11.2个月,中位疾病进展时间(TTP)6.6个月。主要不良反应为骨髓抑制、神经毒性、粘膜炎等。结论多西紫杉醇联合5-氟尿嘧啶、亚叶酸钙及草酸铂治疗胃癌肝转移有效率较高,可提高患者的生存质量,毒副作用能耐受。
Objective To evaluate the effects and adverse reactions of taxotere in Combination with 5-Fluorouracil,Leucovorin and Oxaliplatin regimen for patients with a hepatic metastasis of Gastric Cancer. Methods Taxotere 50mg/ m^2 iv d1, continuous, 5-FU 750 mg/（m^2.d） continuous infusion 48 h d1-2 , CF 200 mg iv d1-3, Oxaliplatin 100 mg/m^2 d1, repeated every 2 weeks. Tumor assessment was done after 3 cycles. Results Among 24 patients, 2 patients reached complete response （CR）, 12 partial responses （PR）. The overall response rate （CR ＋ PR） was 58. 3%. Median survival time was 11.2 months. The median time to progression of all patients was 6. 6 months. The major adverse effect was myelosuppression, mild neurosensory toxicity, and membranitis. Conclusion Taxotere in Combination with 5-Fluorouracil,Leucovorin and Oxaliplatin shows good efficacy in treatment hepatic metastasis of Gastric Cancer. The quality of life can be improved and the toxicity is tolerable.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2007年第9期708-710,共3页
Cancer Research on Prevention and Treatment
关键词
多西紫杉醇
5-氟尿嘧啶
草酸铂
胃肿瘤
肝转移
Taxotere
5-Fluorouracil
Oxaliplatin
Gastric neoplasms
Hepatic metastasis
