摘要
目的：进一步研究青蒿琥酯的免疫作用，采用动物实验方法研究青蒿琥酯对皮肤移植排斥反应的影响。方法：将动物随机分为对照组和青蒿琥酯组，供皮鼠及受皮鼠均用药，分别为７ｄ和１２ｄ。Ｗｉｓｔｅｒ株大鼠作为供皮鼠，将其皮肤移植于ＳＤ株大鼠。结果：对照组和青蒿琥酯组移植皮肤平均存活时间分别为１２．１±２．０８８ｄ和１６．８±３．６３３ｄ（Ｐ＜０．０１）。结论：青蒿琥酯组可显著延长大鼠皮肤移植排斥反应，进一步证实青蒿琥酯的免疫作用。
Objective:To study the immune function of artesunate and the effects of artesunate on experimental skin allograft rejection.Methods:SD strain rats used as skin graft recipient were divided at random into control and experimental groups,and Wister strain rats were used as donor.Artesunate was given to both the experimental group donor and the recipient rats for 7 days and 12 days respectively.Results:The mean survival time of skin grafts in the control group and experimental group was 12.1±2.088 and 16.8±3.633 days,respectively( P <0.01).Conclusions:Artesunate can significantly delay the skin allograft rejection in rats,and the immune function of artesunate was further confirmed.
出处
《蚌埠医学院学报》
CAS
1997年第3期152-153,共2页
Journal of Bengbu Medical College
