摘要
客观: 在老鼠在房间增长和 glomerular mesangial 的关联词 cytokines 分泌物上调查 emodin (EMD ) 的效果。方法: 房间增长和 IL-6 上的 EMD 的效果， TGF- β在老鼠的 glomerular mesangial 的 1 分泌物被观察。房间增长被 MTT 方法测量。IL-6 和 TGF- β 1 分泌物与 ELISA 被检测。结果: EMD 能禁止房间增长和下面调整 IL-6 和 TGF- β glomerular mesangial 的 1 分泌物，作为与在老鼠的模型组相比(P < 0.05 ) 。结论: EMD 能显著地禁止房间增长，并且减少细胞外的矩阵(ECM ) 的创造，这显示它能在 glomerular 的缓和和预防起一个重要作用硬化。机制可以是 EMD 能减少 IL-6 和 TGF- β在老鼠的 glomerular mesangial 房间的 1 分泌物。
Objective：To investigate the effects of emodin（EMD） on cell proliferation and correlative cytokines secretion of glomerular mesangial in rats. Methods：The effects of EMD on cell proliferation and IL-6, TGF-β1 secretion of glomerular mesangial in rats were observed. Cell proliferation was measured by MTT method. IL-6 and TGF-β1 secretion was detected with ELISA. Results：EMD was able to inhibit the cell proliferation and down-regulate the IL-6 and TGF-β 1 secretion of glomerular mesangial, as compared to the model group in rats （P 〈 0.05）. Conclusion：EMD could significantly inhibit the cell proliferation, and reduce the creation of extracellular matrix（ECM）, this indicated that it could play an important role in alleviation and prevention of glomerular sclerosis. The mechanism may be that EMD can reduce the IL-6 and TGF-β1 secretion ofglomerular mesangial cell in rats.
关键词
大黄素
肾小球
细胞增殖
药物疗效
emodin
glomerular mesangial cell
mesangial cell proliferation
correlative cytokines
