摘要
目的研究人类Fascin1基因在子宫内膜癌中的表达及临床意义。方法选取30例新鲜子宫内膜癌组织标本(实验组)及10例正常子宫内膜组织标本(对照组),应用逆转录聚合酶链反应(RT-PCR)研究人类Fascin1基因的表达情况,并分析其与组织学类型、临床分期、病理分级、雌孕激素受体状态的相关性。结果与对照组比较,实验组Fascin1基因表达水平明显升高(P<0.01);Ⅱ期癌组织Fascin1基因表达水平高于Ⅰ期,Ⅲ?Ⅳ期高于Ⅱ期(P<0.05)。结论Fascin1基因的表达随临床分期的上升而增加,Fascin1基因可能参与子宫内膜癌的恶性转化。
[ Objective] To investigate the expression and clinical implication of human Fascinl gene in endometrial carcinoma. [ Methods] The level of human Faseinl gene in endometrial carcinoma tissues （ study group, n = 30） and normal endometrial tissues （ control group, n = 10） was investigated by reverse transcription polymerase chain reaction. Correlation between their expression and histological type, clinical stage, patho-grade, level of estrogen and progesterone reeeptors was studied. [ Results ] There were significant difference of human Faseinl gene between two groups （ P 〈0. 05 ）. The expression of Faseinl gene in stage Ⅱ endometrial carcinoma tissues was higher than that in stage Ⅰ （ P 〈 0. 05）. The expression of Fasein 1 gene in stage Ⅲ and stage Ⅳ was higher than in stage Ⅱ （ P 〈 0. 05）. [ Conclusions ] The expres- sion of human Fasein 1 gene increases with the development of clinical stage. Human Faseinl gene may be related to metastasis of endometfial carcinoma.
出处
《山东医药》
CAS
北大核心
2007年第27期52-54,共3页
Shandong Medical Journal
基金
辽宁省教育厅高等学校科研项目(05L475)
