摘要
目的:探讨血清甲胎蛋白(AFP)、癌胚抗原199(CEA)与肿瘤抗原(CA199)联合检测对原发性肝癌的早期诊断价值。方法:应用电化学发光法联合测定51例原发性肝癌和75例良性肝病(肝硬化、慢性肝炎)患者血清AFP、CEA与CA199的水平。结果:肝癌组血清AFP、CEA和CA199阳性率分别为74.5%、49.0%和45.1%,显著高于良性肝病组(P<0.05);三项联合对肝癌阳性率提高至92.2%、与单项检测相比均有明显差异。结论:3项肿瘤标志物对肝肿瘤的良恶性辅助诊断及鉴别诊断具有一定应用价值,联合检测可以提高原发性肝癌的阳性诊断率。
Objective To study the clinical value of combined detection of the serum levels of AFP, CEA and CA199 in the early diagnosis of primary liver cancer. Methods The serum levels of AFP, CEA and CA199 in 51 patients with primary, hepatic carcinoma, 75 patients with benign liver disease （hepatic cirrhosis, chronic hepatitis）were measured by Electrochemiluminescence. Results Sensitivities of AFP, CEA and CA199 in primary liver cancer group were 74.5% ,49.0% and 45.1%, respectively. They were significantly higher than those in benign liver disease （ P 〈 0.05 ）. Sensitivity of combined detection of three kinds of tumor markers was 92.2%. It was significantly higher than that of single one. Conclusion The detection of AFP, CEA and CA199 are helpful in diagnosis and in differential diagnosis of primary hepatic carcinoma. Combined detection of the three tumor markers increases the detective positive rate.
出处
《实用医技杂志》
2007年第28期3866-3868,共3页
Journal of Practical Medical Techniques
