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血管紧张素转换酶2基因多态性与2型糖尿病肾病的关系 被引量：6

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摘要 目的探讨血管紧张素转换酶2(angiotensin converting enzyme 2,ACE2)基因单核苷酸多态性(single nucleotide polymorphisms,SNP)与2型糖尿病(T2DM)及糖尿病肾病(diabetic nephropathy,DN)的易感性之间的关系。方法采用横断面病例对照研究,应用聚合酶链反应-限制性片段长度多态性检测225例T2DM患者及194例健康对照者的ACE2基因的G8790A多态性,并推测ACE2基因SNP与糖尿病(DM)及DN发病的关系。结果基因型分析显示T2DM组和健康对照组之间G与A基因的分布差异无统计学意义;与T2DM非DN组及健康对照组相比,DN组男性患者A基因频率(59.6%)明显升高,G基因频率(40.4%)明显降低(P<0.05),女性患者A基因频率亦升高,G基因频率降低,但差异没有显著性(P>0.05)。结论ACE2基因多态性与T2DM的易感性可能无关,与DN发生有一定关系,尤其在男性患者更显著。
作者 马增霞 王群 邱书娟 王荣
机构地区 山东大学山东省立医院
出处 《中国老年学杂志》 CAS CSCD 北大核心 2007年第18期1782-1784,共3页 Chinese Journal of Gerontology
关键词 血管紧张素转换酶2 单核苷酸多态性 2型糖尿病 糖尿病肾病
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献10

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二级参考文献5

  • 1Boehm M, Nabel EG.Angiotensin-converting enzyme 2:a new cardiac regulator. N Engl J Med,2002,347:1795-1797.
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共引文献20

同被引文献23

  • 1钟健,祝之明,曹廷兵,闫振成,沈成义,杨华.血管紧张素转换酶2基因多态性与肾脏损害[J].中华内科杂志,2004,43(11):857-858. 被引量：7
  • 2王江,田颖,聂凌,宋熔,谭红梅,祝善俊.心力衰竭患者心肌组织ACE2表达与心功能的关系[J].局解手术学杂志,2007,16(1):13-15. 被引量：6
  • 3郑琦,晋学庆,翁智远,王华军,许昌声,吴可贵.苯那普利、缬沙坦对糖尿病大鼠肾脏血管紧张素转换酶2表达的影响[J].中华高血压杂志,2007,15(6):477-480. 被引量：10
  • 4[3]俸家富,谭同均.应用实验室诊断及进展.四川科学技术出版社,2000:125.
  • 5唐又周,陈鹤群.基于对RAAS系统的认识讨论ACEI和ARB对肾脏系统影响的研究及进展[J].国际泌尿系统杂志,2007,27(6):843-845. 被引量：3
  • 6Mary Donoghue,Frank Hsieh,Elizabeth Baronas,Kevin Godbout,Michael Gosselin,Nancy Stagliano,Michael Donovan,Betty Woolf,Keith Robison,Raju Jeyaseelan,Roger E. Breitbart,Susan Acton.A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9[J].Circulation Research: Journal of the American Heart Association.2000(5)
  • 7Lize Merwe,Ruben Cloete,Miriam Revera,Marshall Heradien,Althea Goosen,Valerie A. Corfield,Paul A. Brink,Johanna C. Moolman-Smook.Genetic variation in angiotensin-converting enzyme 2 gene is associated with extent of left ventricular hypertrophy in hypertrophic cardiomyopathy[J].Human Genetics.2008(1)
  • 8Jian Zhong,Zhengchen Yan,Daoyan Liu,Yinxing Ni,Zhigang Zhao,Shanjun Zhu,Martin Tepel,Zhiming Zhu.Association of angiotensin-converting enzyme 2 gene A/G polymorphism and elevated blood pressure in Chinese patients with metabolic syndrome[J].The Journal of Laboratory and Clinical Medicine.2006(2)
  • 9Koichi Yamamoto,Mitsuru Ohishi,Tomohiro Katsuya,Norihisa Ito,Masashi Ikushima,Masaharu Kaibe,Yuji Tatara,Atsushi Shiota,Sumio Sugano,Satoshi Takeda,Hiromi Rakugi,Toshio Ogihara.Deletion of Angiotensin-Converting Enzyme 2 Accelerates Pressure Overload–Induced Cardiac Dysfunction by Increasing Local Angiotensin II[J].Hypertension.2006(4)
  • 10S. Fr?jd?,L. Sj?lind,M. Parkkonen,V.-P. M?kinen,R. Kilpikari,K. Pettersson-Fernholm,C. Forsblom,J. Fagerudd,C. Tikellis,M. E. Cooper,M. Wessman,P.-H. Groop.Polymorphisms in the gene encoding angiotensin I converting enzyme 2 and diabetic nephropathy[J].Diabetologia.2005(11)

引证文献6

二级引证文献3

中国老年学杂志
2007年 第18期

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