期刊文献+

胃肠道恶性肿瘤患者手术前后CEA mRNA变化及意义 被引量:1

下载PDF
导出
摘要 选择胃肠道恶性肿瘤患者77例(肿瘤组)和良性胃肠道疾病患者64例(对照组),应用RT-PCR方法检测两组血液癌胚抗原信使核糖核酸(CEA mRNA)水平。结果显示,肿瘤组CEA mRNA阳性率明显高于对照组,术后CEA mRNA阳性率明显降低(P均<0.01);CEA mRNA阳性者术后复发率明显高于阴性者(P<0.05)。认为动态检测血液CEA mRNA有助于诊断胃肠道恶性肿瘤血液转移,评价手术效果及预后。
出处 《山东医药》 CAS 北大核心 2007年第28期80-81,共2页 Shandong Medical Journal
  • 相关文献

参考文献4

二级参考文献24

  • 1Miyazono F,Takao S,Natsugoe S,et al.Molecular detection of circulating cancer cells during surgery in patients with billiard-pancreatic cancer.Am J Surg,1999;177:475~479
  • 2Jonas S,Windeatt S,O-Boateng A,et al.Identification of carcinoembryonic antigen-producing cells in blood of patients with colorectal carcinoma by reverse transcriptase plymerase chair reaction.Gut,1996;39:717~721
  • 3Fletcher RH.Carcinoembryonic antigen,1986.
  • 4Zippelius A;Lutterbuse R;Riethmuller G.Analytical variables of reverse transcription-polymerase chain reaction-based detection of disseminated prostate cancer cells,2000.
  • 5Godfrey TE;Raja S;Finkelstein SD.Prognostic value of quantitative reverse transcription-polymerase chain reaction in lymph node-negative esophageal cancer patients clin[J],2001.
  • 6Mori M;Mimori K;Inoue H.Detection of cancer micrometastases in lymph nodes by reverse transcription-polymerase chain reaction,1995.
  • 7Caldas C.Molecular staging of cancer: is it time? L,1997.
  • 8Luketich JD;Kassis ES;Shriver SP.Detection of micrometastases in histologically negative lymph nodes in esophageal cancer,1998.
  • 9Mori M,Mimori K,Inoue H,et al.Detection of cancer micrometastases in lymph nodes by reverse transcriptase-polymerase chain reaction[].Cancer Research.1995
  • 10Jonas S,Windeatt S,O-Boateng A,et al.Identification of carcinoembryonicantigen-producing cells circulating in the blood of patients with colorectal carcinoma by reverse transcriptase polymerase chain reaction[].Gut.1996

共引文献25

同被引文献22

  • 1敖亚洲,胡建功,史丽民,王晓杰,胡大为,薛承岩.CEAm RNA和TA对诊断消化系统肿瘤远处转移的价值[J].中国肿瘤临床,2005,32(18):1061-1063. 被引量:6
  • 2张建华,钟怀印,薛承岩.CEAmRNA-CEAp系统在良恶性腹水中表达差别的临床意义[J].第四军医大学学报,2005,26(24):2277-2279. 被引量:6
  • 3Gerhard M, Juhl H, Kalthoff H, et al. Specific detection of carcinoembryonic antigen - expressing tumor cells in bone marrow aspirate by polymerase chain reaction [ J ]. Clin Oncol, 1994, 12 : 725- 729.
  • 4Mori M, Mimori K, Inoue H, et al. Detection of cancer micrometastasis in lymph nodes by reverse transcriptase - polymerase chain reaction [ J ]. Cancer Res, 1995, 55 : 3417 - 3420.
  • 5Ho SB, Hyslop A, Albrecht R, et al. Quantification of coorectal cancer micrometastases in lymph nodes by nested and real -time reverse transcriptase- PCR analysis for carcinombryonic antigen[ J]. Clin Cancer Res, 2004, 10:5777 - 5784.
  • 6Oberg AN, Lindmark GE, Israelsson AC, et al. Detection of occult tumour cells in lymph nodes of colorectal cancer patients using real - time quantitative RT- PCR for CEA and CK20 Mrnas [ J ]. Int Cancer, 2004, 111(1): 101-110.
  • 7Mori M, Mimori K, Ueo H, et al. Molecular detection of circulating solid carcinoma cells in the peripheral blood: the concept of early systemic disease[J]. Int cancer, 1996, 68:739 -743.
  • 8Miyazono F, Takao S, Natsugoe S, et al. Molecular detection of circulating caner ceils during surgery in patients with biliary -pancreatic cancer [J]. Am Surg. 1997, 177:475 -479.
  • 9Schuster R, Max N, Mann B, Heufelder K, et al. Quantitative real - time RT - PCR for detection of disseminated tumor cells in peripheral blood of patients with colorectal cancer using different mRNA markers [ J ]. Int Cancer, 2004, 108(2) : 219 -227.
  • 10Guadagni F, Kantor J, Aloe S, et al. Detection of blood - borne cells in colorectal cancer patients by nested reverse transcriptase -polymerase chain reaction for carcinoembryonic antigen message RNA: longitudinal analyses and demonstration of its potential importance as an adjunct to multiple serum markers [J]. Cancer Res, 2001, 61:2523 - 2532.

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部