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肝纤维化血清学诊断研究 被引量：4

Research in diagnosing hepatic fibrosis with serological parameters
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摘要 肝纤维化是指肝细胞发生坏死及炎症刺激时，肝脏中胶原蛋白等ECM增生与降解失去平衡，导致肝脏内纤维结缔组织异常沉积的病理过程，轻者称为纤维化，重者进而合并肝小叶结构改建、假小叶及再生结节形成，称为肝硬化。肝穿刺组织病理学检查是诊断肝纤维化的金标准。然而，其作为一种创伤性检查方法，有潜在并发症，不易为患者接受。
作者 杨冬华 刘浏 汤绍辉
机构地区 暨南大学附属第一医院消化内科
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2007年第9期718-720,共3页 Chinese Journal of Hepatology
关键词 肝纤维化 诊断 血清学指标 预测模型 Liver fibrosis Diagnosis Serologic index Predictive model
分类号 R686 [医药卫生—骨科学]
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参考文献20

  • 1Dienstag JL. The role of liver biopsy in chronic hepatitis C. Hepatology, 2002, 36(5 Suppl 1): S152-160.
  • 2Standish RA, Cholongitas E, Dhillon A, et al. An appraisal of the histopathological assessment of liver fibrosis. Gut, 2006, 55: 569- 578.
  • 3Poynard T, Munteanu M, Imbert-Bismut E et al. Prospective analysis of discordant results between biochemical markers and biopsy in patients with chronic hepatitis C. Clin Chem, 2004, 50: 1344- 1355.
  • 4Kaneda H, Hashimoto E, Yatsuji S, et al. Hyaluronic acid levels can predict severe fibrosis and platelet counts can predict cirrhosis in patients with nonalcoholic fatty liver disease. J Gastroenterol Hepatol, 2006, 21: 1459-1465.
  • 5Leroy V, Monier F, Bottari S, et al. Circulating matrix metalloproteinases 1, 2, 9 and their inhibitors TIMP-1 and TIMP-2 as serum markers of liver fibrosis in patients with chronic hepatitis C: comparison with PIIINP and hyaluronic acid. Am J Gastroenterol, 2004,99:271-279.
  • 6Rosenberg WM, Voelker M, Thiel R, et al. Serum markers detect the presence of liver fibrosis: a cohort study. Gastroenterology, 2004, 127: 1704-1713.
  • 7Halfon P, Bourliere M, Deydier R, et al. Independent prospective multicenter validation of biochemical markers (fibrotest-actitest) for the prediction of liver fibrosis and activity in patients with chronic hepatitis C: the fibropaca study. Am J Gastroenterol, 2006, 101: 547-555.
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二级参考文献16

  • 1Giannini E,Ceppa P,Botta F,et al.Steatosis and bile duct damage in chronic hepatitis C:distribution and relationships in a group of Northern Italian patients.Liver,1999,19:432-437.
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  • 3Aster RH.Pooling of platelets in the spleen:role in the pathogenesis of "hypersplenic" thrombocytopenia.J Clin Invest,1996,45:645-657.
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  • 5Dienstag J.The role of liver biopsy in chronic hepatitis C.Hepatology,2002,36(5suppl):S152-160.
  • 6Bedossa P,Dargere D,Paradis V.Sampling variability of liver fibrosis in chronic hepatitis C.Hepatology,2003,38:1449-1457.
  • 7Bissell DM.Assessing fibrosis without a liver biopsy:are we there yet? Gastroenterology,2004,127:1847-1849.
  • 8Rosenberg WM,Voelker M,Thiel R,et al.Serum markers detect the presence of liver fibrosis:a cohort study.Gastroenterology,2004,127:1704-1713.
  • 9Imbert-Bismut F,Ratziu V,Pieroni L,et al.Biochemical markers of liver fibrosis in patients with hepatitis C virus infection:a prospective study.Lancet,2001,357:1069-1075.
  • 10Forns X,Ampurdanes S,Lovet JM,et al.Identification of chronic hepatitis C patients without hepatic fibrosis by a simple predictive model.Hepatology,2002,36:986-992.

共引文献80

同被引文献24

引证文献4

二级引证文献19

中华肝脏病杂志
2007年 第9期

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