摘要
为探讨皮下超量灌注吸脂术的安全性如何,通过分段采血方法测定血利多卡因浓度观测其药物代谢动力学(以下简称药代动力学)变化。研究结果表明:利多卡因的吸收缓慢,血浆波峰浓度平均1.16μg/ml,一般在皮下灌注后4～13小时出现。波峰浓度(Y:μg/ml)与利多卡因用量(X:mg/kg)明显相关,相关方程式:Y=-0.494+0.071X,r=0.934,P<0.001。认为皮下超量灌注吸脂术是安全、有效的去脂方法。
The purpose of this study was to evaluate the pharmacokinetics of lidocaine in the pa- tients undergoing liposuction after subcutaneous infiltration of 0.06% lidocaine.It was found that the absorption of lidocaine was slow.The mean peak concentration of lidocaine that was 1.16ug/mg with a range of 0.67 to 2.84ug/mg occurred 4—13 hours after lidocaine administration.The peak concentration (Y) was correlated with the dose(X) of lidocaine,which was drawn as Y=-0.494+0.071X.(r= 0.934,P<0.001).We concluded that the tumescent technique is an effective and safe method for the patients undergoing liposuction.
