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促性腺激素释放激素激动剂对卵巢黄素化颗粒细胞甾体激素合成急性调节蛋白表达的影响 被引量:1

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摘要 自上世纪90年代开始,促性腺激素释放激素激动剂(gonadotropin-releasinghormoneagonist,GnRH—a)被广泛用于辅助生育技术领域控制性超排卵治疗中。近年来,人们逐渐认识到GnRH-a在提高获卵数量和妊娠率的同时,存在着对垂体和卵巢黄体的过度抑制作用。前期研究显示,在不同剂量GnRH-a降调节方案中,启动日血清黄体生成素(LH)、雌二醇水平以及人绒毛膜促性腺激素(hCG)注射日的LH、雌二醇、孕酮水平存在差异。本研究针对这一现象,通过对GnRH-a降调节的体外受精-胚胎移植(invitrofertilizationandembryotransfer,IVF-ET)周期中卵巢黄素化颗粒细胞甾体激素合成的关键性调节蛋白——甾体激素合成急性调节蛋白(steroidogenicacuteregulatoryprotein,StAR)表达的实验研究,探讨GnRH-a剂量对黄体功能影响的程度和机制,为选择GnRH-a降调节方案和改善黄体支持方案提供实验依据。
出处 《中华妇产科杂志》 CAS CSCD 北大核心 2007年第9期631-632,共2页 Chinese Journal of Obstetrics and Gynecology
基金 广东省自然科学基金(2003-31691)
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参考文献7

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二级参考文献6

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