摘要
microRNAs（miRNAs）是人类新发现的一类非编码小分子RNA，广泛分布于真核细胞内。miRNAs通过与靶基因互补位点配对结合，在转录后水平负性调控靶基因的表达，参与生长发育、细胞增殖、细胞凋亡、细胞分化等生命过程。据推测，大约1％的人类已知基因编码miRNAs，而miRNAs可调控人类基因组中10％-30％的基因。本文就如何识别miRNAs及其靶基因作一简要介绍。
karyotes and microRNAs （miRNAs） are a recently discovered family of small non-coding RNAs, which exist in euregulate gene expression post-transcriptionally by binding to complementary sites MiRNAs play important roles in regulation of cell proliferation, development, apoptosis and cell on target mRNAs. differentiation. It＇ s predicted that about 1% human known genes encode microRNAs and microRNAs may regulate 10 - 30% of the genes in the human genome. The paper focus on the knowledge about how to recognize miRNAs and identify their target mRNAs.
出处
《基础医学与临床》
CSCD
北大核心
2007年第9期1063-1065,共3页
Basic and Clinical Medicine
