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TRB3与胰岛素抵抗 被引量：1

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摘要 Tribbles是最近几年新发现的一个假性蛋白激酶家族，其特有的生物学特性及其在癌症和糖尿病发生发展过程中对细胞信号传导通路和生化过程的调控作用，引起了研究人员的广泛关注。其中，TRB3与胰岛素抵抗的关系尤为引人注目。现就Tribbles家族、TRB3及其与胰岛素抵抗关系的研究做一简要概述。
作者 侯香华 关广聚
机构地区 山东大学第二医院肾内科
出处 《中华医学杂志》 CAS CSCD 北大核心 2007年第38期2730-2732,共3页 National Medical Journal of China
关键词 胰岛素抵抗 细胞信号传导通路 蛋白激酶家族 生物学特性 调控作用 研究人员 糖尿病
分类号 R587.1 [医药卫生—内分泌]
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参考文献28

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同被引文献9

  • 1Stuebe AM, Mantzoros C, Kleinman K, et al. Gestational glucose tolerance and maternal metabolic profile at 3 years postpartum [ J ]. Obstet Gynecol, 2011,118 ( 5 ) : 1065.
  • 2Kato S, Du K. TRB3 modulates C2C12 differentiation by in- terfering with Akt activation [ J ]. Biochem Biophys Res Commun, 2007,353 ( 4 ) : 933.
  • 3Holemans K,Caluwaerts S,Poston L, et al. Diet-induced o- besity in the rat: a model for gestational diabetes mellitus [J]. Am J Obstet Gynecol,2004,190(3) :858.
  • 4Bowers A J, Scully S, Boylan JF. SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia [ J ]. Oneogene,2003,22 ( 18 ) :2823.
  • 5Li X, Monks B, Ge Q, et al. Akt/PKB regulates hepatic me- tabolism by directly inhibiting PGC-lalpha transcription coactivator [ J ]. Nature ,2007,447 ( 7147 ) : 1012.
  • 6Du K, Herzig S, Kulkarni RN, et al. TRB3 : a tribbles hom- olog that inhibits Akt/PKB activation by insulin in liver [ J ]. Science, 2003,300 ( 5625 ) : 1574.
  • 7He L, Simmen FA, Mehendale HM, et al. Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane. Role of TRB3 in inhi- bition of Akt/protein kinase B activation[ J]. J Biol Chem, 2006,281(16) :11126.
  • 8李变锋,辛亚萍,王崇贤,张苏河.高脂高糖喂养诱导妊娠期胰岛素抵抗大鼠模型的建立与评价[J].广东医学,2013,34(11):1667-1669. 被引量：3
  • 9李变锋,付艳芹,张东铭,张苏河.饮食干预对高脂高糖诱导的妊娠期大鼠胰岛素抵抗状态的影响[J].郑州大学学报（医学版）,2013,48(4):499-502. 被引量：4

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中华医学杂志
2007年 第38期

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