摘要
目的探讨中国北方地区汉族人同型半胱氨酸(homocysteine,Hcy)与糖尿病并发冠心病发生的关系。方法研究对象均为北方汉族人群,包括92名糖尿病并发冠心病患者,67名糖尿病患者,80名冠心病患者和对照组95名健康人。应用荧光偏振免疫法(FPIA)测定Hcy水平,应用微粒子酶免分析免疫法(MEIA)测定血浆叶酸、维生素B12浓度。同时测定各种血脂。采用SPSS11.0软件进行统计学分析。结果糖尿病并发冠心病组(并发组)Hcy平均水平(中位数)(15.1μmol/L)显著高于对照组(11.7μmol/L)和糖尿病组(10.9μmol/L),而低于冠心病组(16.6μmol/L)(P<0.05),对照组与糖尿病组之间差别无统计学意义(P>0.05)。并发组叶酸、维生素B12明显低于正常对照组及糖尿病组,明显高于冠心病组(P<0.05)。Logistic回归分析显示高同型半胱氨酸血症、年龄、TC是糖尿病并发冠心病发生的独立危险因素,OR值分别为3.507,1.085,1.021。结论高同型半胱氨酸血症是中国北方地区汉族人2型糖尿病并发冠心病发生的独立危险因素,可能在糖尿病并发冠心病的发生、发展过程中起到一定作用。
Objective To explore the significance of hyperhomocysteinemia in type 2 diabetes mellitus （DM） with coronary heart disease（CHD） in northern China. Methods Selected 92 patients with type 2 DM and CHD, 67 patients with type 2 DM, 80 patients with CHD,and 95 healthy controls in Han nationality in northern China. Plasma Hcy levels were measured by fluorescence polarization immunoassay （FPIA）and the plasma folate and vitamin B12 levels by microparticle enzyme immunoassay（MEIA）. Results The plasma Hcy levels in DM with CHD group（15.1 μmol/L）were significantly higher than in control group（11. 7 μmol/L）and DM group（10. 9 μmol/L） ,but lower than in CHD group（16. 6 μmol/L）, （P〈0.05）. The levels of plasma folate and vitamin B12 in DM with CHD group were significantly lower than in control group and DM group, but higher than in CHD group （P〈0.05）, Logistic-regression analysis indicated that hyperhomocysteinemia ,age and TC were the independent risk factors for CHD, Conclusion Hyperhomocysteinemia was the independent risk factors for DM with CHD in northern Chinese Han population. Hcy may be involved in the pathogenesis and development of CHD in type 2 DM.
出处
《现代检验医学杂志》
CAS
2007年第5期91-93,共3页
Journal of Modern Laboratory Medicine
关键词
高同型半胱氨酸血症
2型糖尿病
冠心病
hyperhomocysteinemia
type 2 diabetes mellitus
coronary heart disease
