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CTLA-4基因微卫星多态性与子宫内膜异位症的相关性研究

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摘要 目的：研究CTLA-4基因微卫星多态性与子宫内膜异位症（EM）的相关性。方法：采用聚合酶链反应技术-扩增片段长度多态性技术,分析56例EM患者和35例对照者CTLA-4基因外显子4的3’非翻译区,包含（AT）n重复序列的特异性等位基因。结果：EM患者CTLA-4基因外显子4的3’非翻译区（AT）n重复序列有12种等位基因。与对照组比较,120bp等位基因频率在EM组中显著增高,差异有统计学意义（P〈0.01,OR=3.344,95%CI1.498-7.464）;CTLA-4（AT）n120bp等位基因频率在EM临床各期分布无明显差异（P〉0.05）。结论：CTLA-4基因外显子4的3′非翻译区（AT）n重复序列多态性与EM相关;CTLA-4（AT）n重复序列120bp等位基因可能是EM的易感基因。
作者 马燕 余健 欧奇志 龙凤宜 徐红 罗佐杰
机构地区 广西医科大学第一附属医院妇产科 广西医科大学第三附属医院妇产科 广西医科大学第一附属医院内分泌科
出处 《广西医科大学学报》 CAS 北大核心 2007年第4期591-594,共4页 Journal of Guangxi Medical University
基金 广西壮族自治区卫生厅项目(Z2002015)
关键词 子宫内膜异位症 CTLA-4基因 多态性
分类号 R711.71 [医药卫生—妇产科学]
  • 相关文献

参考文献10

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二级参考文献13

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广西医科大学学报
2007年 第4期

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