摘要
目的研究肝衰竭患者并发细菌与真菌双重感染的临床特点。方法以我院1986年1月至2006年6月收治的肝衰竭患者合并细菌和真菌双重感染者为研究对象，细菌感染需有临床表现和病原学阳性，统计分析相关资料。结果真菌感染者共507例，合并细菌和真菌双重感染者132例。132例中慢性重型肝炎85例（64．39％），失代偿期活动性肝硬化40例（30．3％）。细菌感染153例次，医院感染发生率为54．90％。分离出细菌204株，G^- 杆菌143株（70．10％）、G^＋ 球菌61株（29．90％）。腹腔感染占首位，共122例次，其次为肺部30例次。真菌感染143例次，医院感染发生率为86．71％。分离出真菌155株，其中白色念珠菌90株（58．06％），烟曲霉菌17株（10．97％），非白色念珠菌25株（16．13％）。肺部感染占首位（94例次），其次为口腔（53例次）。治疗后无效和死亡84例（63．64％）。结论失代偿期活动性肝硬化和慢性重型肝炎是继发细菌和真菌感染的主要人群。真菌的医院感染发生率高于细菌。继发真菌感染的患者预后差。
Objective To study clinic character of liver failure complicated with bacterium and fungous infection. Methods The patients with liver failure complicated with bacterial and fungous infection who were treated in our hospital from January 1986 to June 2006 were studied, All patients had clinical manifestation and positive of bacterium. The data were statistical analysis. Results 507 patients diagnosed with fungous infection were found from January 1986 to June 2006 in which 132 patients were diagnosed with bacterial and fungous infection. There were 85 patients （64.39%） with chronic severe hepatitis and 40 patients （30.3%） with decompensation cirrhosis. Bacterial infection happened in 153 cases in which the rate of nosocomial infections was 54.90% . 204 bacterial strains were separated in which 143 strains （70.10%） were gram-negative bacterium and 61 （29.90%） strains were gram-positive bacterium. The main sites of bacterial infection were abdominal cavity （122 cases） and lung （30 cases）, Fungous infection happened in 143 cases in which the rate of nosocomial infections was 86.71%. 155 fungous strains were separated in which 90 strains （58.06%） were Candida albicans, 17 strains （ 10.97% ） were Aspergillus fumigatus and 25 （ 16.13 % ） strains were non-Candida albicans. The main sites of fouguns infection were lung （94 cases） and mouth （53 cases）. 84 patients （63.64%） were ineffectived and died after treatment. Conclusion The patients with decompensation cirrhosis and chronic severe liver hepatitis were easy to be infected by bacterial and fungous. The rate of fungous nosocomial infections is higer than that of bacterium. The prognosis is bad in patients who had secondary fungous infection.
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
北大核心
2007年第3期229-231,共3页
Chinese Journal of Experimental and Clinical Virology
关键词
肝功能衰竭
感染
细菌感染和真菌病
真菌
Liver failure
Infection
Bacterial infection and mycoses
Fungi
