摘要
研究１１年间菌血症患者细菌感染谱和耐药性的变迁。方法用纸片扩散法对由菌血症患者分离出的细菌进行药敏试验。结果表皮葡萄球菌菌血症的构成增高非常显著。在金黄色葡萄球菌（以下简称金葡菌）菌血症中，耐甲氧西林金葡菌（ＭＲＳＡ）菌血症的构成增高非常显著。ＭＲＳＡ和对甲氧西林敏感的金葡菌（ＭＳＳＡ）对青霉素和庆大霉素的耐药性增高均非常显著。与１９８６～１９９０年比较，１９９１～１９９６年，表皮葡萄球菌对青霉素、红霉素和甲氧西林的耐药性增高非常显著，绿脓杆菌对羧苄西林和哌啦西林的耐药性，大肠杆菌对庆大霉素和头孢哌酮的耐药性，克雷白菌对氨苄西林和羧苄西林的耐药性增高均非常显著。产生诱导型β－内酰胺酶的肠杆菌科细菌对第一至第三代头孢菌素均有较高的耐药性。
Objective To study the changes in patterns and resistances of bacteria from patients with bacteremiain 11 years.Methods Diffusion tests were used to measure the antibiotic sensitivity of bacteria isolated from the patients with bacteremia.Results The proportion of staphylococcus epidermidis in bacteremia increased significantly.The proportion of methicillin resistant Staphylococcus aureus(MRSA) in bacteremia caused by staphyiococcus increased markedly.Resistance of MRSA and methlcillin sensi tive staphylococcus aureus(MSSA) to penicillin,and gentamycin increased significantly.Compared 1986 1990,with1991 1996,the resistance of S.epidermidis to penicillin,erythromycin, and methicillin increased markedly,so did resistance of pseudomonas aeruginosa to carbenicillin,and piperacillin,resistance of E.coli to gentamycin and cefoperazone,resistance of klebsiella to ampicillin and carbenicillin.The resistance of enterobacteriaceae which induced β lactamase to the first to the third generation of cephalosporins was relatively high.Conclusion The resistance of bacteria to the commonly used antibiotics was produced in various degrees.
出处
《中华医学杂志》
CAS
CSCD
北大核心
1997年第5期332-335,共4页
National Medical Journal of China
