摘要
目的:研究奥曲肽(Octreotide)治疗晚期癌性肠梗阻的作用。方法:晚期癌性肠梗阻非手术治疗患者60例分为两组:对照组(n=30)常规治疗,即禁食、鼻胃管胃肠减压、镇痛、全肠外营养支持;治疗组(n=30)除常规治疗外,使用奥曲肽治疗,剂量为0.1 mg,皮下注射,3次/d。观察两组治疗开始前1 d、治疗第4和第7 d的鼻胃管引流量。当鼻胃管引流量≤100 ml/d时,拔除鼻胃管,同时观察两组的鼻胃管拔除率。结果:与对照组相比,治疗组治疗第4 d胃液引流量显著减少[(527±217)ml/dvs(900±249)ml/d,P<0.05)],治疗第7 d进一步减少[(60±143)ml/dvs(525±163)ml/d,P<0.01)];治疗组患者鼻胃管拔除率显著提高(83.3%vs16.7%,P<0.01)。结论:奥曲肽可显著减少胃液的引流量,使大部分患者摆脱胃肠减压,在晚期癌性肠梗阻患者非手术治疗中具有重要作用。
Objective ： To evaluate the role of octreotide in the management of advanced malignant bowel obstruction. Methods： Sixty patients with inoperable malignant bowel obstruction received octreotide 0.3 mg daily （ n = 30） or routine therapy （ n = 30）. Diagnosis was made on the clinical grounds and confirmed by plain abdominal radiography and CT. The volume of drainage fluid from the nasogastric tube and the rate of the nasogastric tube removals were assessed at the baseline, fourth and seventh day of the treatment, respectively. Results：Data analysis showed statistically significant differences between the two groups. A week of octrotide treatment further recluced the drainaged gastrointestinal fluid （ [ 60 ± 143] ml/d vs[525 ± 163] ml/d,P 〈0.01） and raised the rate of gastric tube removals （83.3% vs 16.7% ,P 〈 0.01 ）. Conclusion： Octreotide is an effective drug for the palliative treatment in malignant bowel obstruction.
出处
《医学研究生学报》
CAS
2007年第10期1044-1046,共3页
Journal of Medical Postgraduates
基金
江苏省社会发展基金资助项目(批准号:BS20070045)
关键词
奥曲肽
癌
肠梗阻
Octreotide
Cancer
Bowel obstruction
