摘要
目的：观测川芎嗪对剪切应力诱导血小板聚集（ＳＩＰＡ）的影响。方法：采用新研制的激光散射剪切装置观测川芎嗪及对照药Ａｓｐｉｒｉｎ在体内外对抗ＳＩＰＡ的作用。结果与结论：Ａｓｐｉｒｉｎ能抑制ＡＤＰ诱导的血小板聚集，但不能抑制ＳＩＰＡ。川芎嗪在体内（２５～５０ｍｇ·ｋｇ－１）体外（９．２～７３．４ｍｍｏｌ·Ｌ－１）均有显著抗ＳＩＰＡ作用（Ｐ＜０．０１），其机制待进一步研究。
AIM: The effect of ligustrazini on shear induced platelet aggregation (SIPA) was investigated. METHODS: A newly developed laser scattering shear generator was employed to evaluate in vitro and in vivo effects of ligustrazini and control drug aspirin on SIPA. RESULTS AND CONCLUSION: Aspirin could inhibit platelet aggregation induced by ADP, but could not inhibit SIPA. Ligustrazini inhibited SIPA in both in vitro (at dosage of 25 to 50 mg·kg -1 ) and in vivo (at dosage of 9 2 to 73 4 mmol·L -1 ) tests significantly.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1997年第1期47-50,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金
关键词
川芎嗪
剪切应力
血小板聚集
药理学
ligustrazini
shear stress
platelet aggregation 1Beijing Xuanwu Hospital, Beijing Geriatric Clinical and Research Center, Beijing 100053
