摘要
目的:探讨新生儿脐血中胰岛素样生长因子-I(IGF-I)和胰岛素样生长因子结合蛋白-3(IGFBP-3)水平与胎儿宫内生长发育的关系。方法:采用放射免疫分析,分别对出生时体重正常新生儿与宫内生长迟缓的低体重新生儿脐血的IGF-I及IGFBP-3水平进行检测。结果:宫内发育迟缓组新生儿脐血的IGF-I及IGFBP-3的含量明显低于正常对照组(P<0.01),有显著差异性。结论::IGF-I和IGFBP-3与胎儿宫内生长发育密切相关,对胎儿的宫内生长发育起着重要的调节作用。
Objective To study the relationship between fetal development and cord serum insulin - like growth factor - I （ IGF -I）, IGF binding protein -3 （IGFBP -3） levels at birth. Mothods Cord serum IGF-I and IGFBP-3 levels were measured with IRMA in 45 neonates with normal birth weight and 32 neonates with IUGR. Results The cord seurm levels of IGF - I and IGFBP - 3 in neonates with intrauterine growth retardation were significantly lower than those in neonates with normal birth weigt （P 〈0. 01 ）. Conclusion Cord serum levels of ICF - I and ICFBP - 3 are closely correlated with growth parameters and may play an importaat role in the regulation of fetal growth.
出处
《放射免疫学杂志》
CAS
2007年第5期404-405,共2页
Journal of Radioimmanology
