摘要
目的探讨正常妇女与PCOS妇女促排卵治疗后着床期子宫内膜容受性相关因子的改变,包括整合素αv、MMP9、TIMP1、VEGF和LIF的表达。方法12例正常妇女自然周期(对照组)和8例PCOS患者经过促排卵治疗后(P-COS组)均在着床期取子宫内膜进行integrinαv、MMP9、TIMP1、VEGF和LIF免疫组化染色,并进行统计学分析。结果PCOS组E2、P水平高于正常组,但E2/P比值变化幅度大,PCOS组着床期子宫内膜中integrinαv、MMP9、TIMP1、VEGF和LIF表达均弱于对照组。结论PCOS患者促排卵治疗后E2、P分泌不协调,导致着床期子宫内膜integrinαv、MMP9、TIMP1、VEGF和LIF表达减弱,进而影响着床过程中的多个环节,这可能是造成PCOS患者促排卵治疗后高排卵率、低妊娠率和高流产率的原因之一。
Objective： To study the different receptivity of the endometrium during the implantation window time in normal women and PCOS patients. Methods： The twelve normal women with regular menstruation and the eight PCOS patients received ovulation induction therapies. Endometrial dating and biopsy, immunohistochemical determination of integrinαv, MMP9, TIMP1, LIF and VEGF expression. Results ： The level of E2, P and E2 ： P ratio is uncorrelated in PCOS. The expression of integrinαv, MMP9, TIMP1, VEGF and LIF in PCOS groups is weaker than normal women. Conclusion ： This study may provided that the abnormal secretion of E2 and P in PCOS makes the low expression of integrinαv, MMP9, TIMP1, VEGF and LIF and the change of endometrial function during the implantation window time, this maybe one of the causes of poor pregnant rate and high miscarriage rate in PCOS.
出处
《中国优生与遗传杂志》
2007年第10期23-25,F0002,F0003,共5页
Chinese Journal of Birth Health & Heredity
基金
国家自然科学基金资助项目(编号:30070785)~~
