摘要
目的：探讨激素替代治疗（HRT）的安全性。方法：2002年1月-2007年1月用HRT治疗绝经期妇女106例,应用尼尔雌醇和安宫黄体酮。每半年进行妇科、乳腺的B超检查,每年进行血生化系列检查。结果：用药后高密度脂蛋白胆固醇（HDL-C）明显上升（P〈0.05）,低密度脂蛋白胆固醇（LDL-C）明显下降（P〈0.05）,甘油三脂（TG）无明显变化。子宫出血例数在绝经初期为多,用药后子宫内膜厚度和乳腺增生程度无明显增加。结论：定期对接受HRT的妇女进行检查和评价,使HRT的应用更为安全有效。
Objective： Discussing the safety of HRT.Methods： A total of 106 cases was postmenopausal women treated with HRT used nilestriol and medroxyprogesterone during 2002-2007.Every half year they carried on the gynecology department and the mammary gland B ultra inspection, carried on the blood biochemistry series of inspection every yearo Results： After the therapy their high density lipoproteln cholesterol rose significantly （P〈0.05）, the low density lipoprotein cholesterol dropped significantly （P〈0.05）. Their glycerin trinitrate fat didn＇t change obviously.The uterine bleeding was frequent in the menopause initial period.The endometrial thickness and the mammary gland proliferation degree did not significantly increase after the medicine.Conclusion： If women who accept the HRT carry on the inspection and the appraisal regularly, HRT application will be more effective.
出处
《中国医药导报》
CAS
2007年第10X期151-152,共2页
China Medical Herald
关键词
激素替代治疗
子宫内膜
血脂
Hormone replacement therapy
Endometrial
Lipids
