摘要
目的探讨PHC组织中MC和MV计数的相互关系。方法应用ABC免疫组化法对50例PHC手术切除标本常规石蜡包埋切片,分别检测MV和MC计数。结果50例PHC癌组织MV、MC计数均显著高于癌旁组织(MV:69.45±14.68vs35.29±10.95,P<0.01;MC:16.90±5.59vs9.88±3.59,P<0.05);AFU<10μg/mL、有转移、肿块直径>5cm的癌组织MV计数均显著高于AFU>10μg/mL、无转移、肿块直径<5cmMV计数(AFU:71.31±12.03vs57.88±11.69,P<0.05;转移:75.50±13.70vs58.18±11.68,P<0.05;肿块直径:80.33±13.88vs60.71±14.50);癌组织中MC计数与MV计数呈密切正相关(r=0.388,P<0.05)。结论MC、MV计数与PHC的发生、进展关系密切。
Objective To study on the counts of microvessel and mast cell in the tissues of primary hepatocareinoma and detect the relation to the clinicopathological features of PHC, and the relationship between the counts of MC and MV. Methods The stains of MV and MC were completed by the immunohistochemical method of avidin-biotin complex in routine paraffin-embedded sections from 50 cases with PHC. Reaults The count means of MV and MC in the cancer tissues were significantly higher than that in the precancerous tissues（MV： 69.45 ± 14.68 vs 35.29 ± 10.95, P 〈 0.01; MC： 16.90 ±5.59 vs 9.88 ± 3.59, P 〈 0.05）; the count of MV in the patients with AFU（pre-operation） 〈 10 μg/mL in serum（71.31 ± 12.03） was significantly higher than that whose AFU 〉 10 μg/mL（57.88 ±11.69）（P 〈 0.05） and the count of MV in the patients with metastasis（75.50 ± 13.77） was significantly higher than that of non-metastasis（58.18 ± 11.68）（P 〈 0.05）; the count of MV in the patients with mass diameter 〈 5cm（80.33 ± 13.88） was significantly higher than that of mass diameter 〉 5cm（60.17 ± 14.50）; the count of MC was significantly correlated with the count of MV（r= 0.388, P 〈 0.05）. Conclusion The count of MC and MV might be closely related to the car cinogenesis and the progress of PHC.
出处
《中国现代医生》
2007年第10X期13-15,共3页
China Modern Doctor
关键词
原发性肝癌
微血管
巨噬细胞
计数
免疫组织化学
Primary hepatoearcinoma
Microvessel
Mastcell
Count
Immuno-histochemistry
