摘要
目的验证纳洛酮冲击疗法、纳曲酮冲击疗法的临床效果,探讨纳曲酮长效缓释剂包埋术的防复吸效能。方法需脱毒者采用NTX冲击疗法或NLX冲击疗法快速脱毒,次日进行NTX长效缓释剂包埋术,观察冲击疗法临床效果,随访出院后稽延性戒断症状及防复吸效能。结果100例中,已完成脱毒者7例,采用NTX冲击治疗者36例,采用NLX冲击治疗者57例,次日进行包埋术,无一例出现严重戒断症状,冲击成功率100%,出现无菌性炎症4例,稽延性戒断症均在1个月以内消除,半年操守率96.8%。结论NLX或NTX冲击疗法具有时间短、脱毒快、彻底、成功率高的优点,经得起临床验证。NTX长效缓释剂有较好的防复吸效能,很有临床实用价值。
Objective To evaluate the clinical effect of the warp operation of long-effective slow-released naltrexone after rapid and high dose of NTX or NLX therapy. Methods A group： 57 patients had completed rapid and high dose of NLX therapy in 3 days. B group： 36 patients had completed rapid and high dose of NTX therapy. C group： 40 patients had completed Methadose therapy, warp operation of long-effective slow-released naltrexone had completed in the second afternoon of A group and B group.Withdrawal Symptoms and side effects were observed and the outpatients were phoned. Results The average time from admission to the treatment was（2.3 ± 0.6） days of A group and （6.4 ± 0.6） days of B group. All patients were operated in the next afternoon. Withdrawal symptoms and side effects were little. Success rate was 100%. The abstinence rate in 6 months in A group and B group（96.8%）was higher than that of C group（2.5%）. Conclusion The time of detoxification of rapid and high dose of the therapy is rapid, short and curative rate of the therapy is high, its clinical effect is affirmed. Warp operation of long-effective slow-released naltrexone prevention of relapse is effective and has clinical application value.
出处
《中国现代医生》
2007年第10X期18-20,23,共4页
China Modern Doctor
关键词
纳洛酮冲击疗法
纳曲酮冲击疗法
纳曲酮长效缓释剂
防复吸治疗
海洛因依赖
Rapid and high dose of NTX or NLX therapy
Warp operation of long-effective slow-released naltrexone
Effect of prevention relapse
Heroin dependence
