摘要
目的研究2型糖尿病合并冠心病患者糖化血红蛋白与凝血因子Ⅶ的相关性。方法对40例2型糖尿病患者(简称糖尿病组)和73例2型糖尿病合并冠心病患者(简称合并病组)进行糖化血红蛋白水平及血浆凝血因子Ⅶ活性的检测。结果合并病组凝血因子Ⅶ活性水平明显高于糖尿病组(P<0.05),其中合并急性心肌梗死及不稳定型心绞痛患者凝血因子Ⅶ活性明显升高(P<0.01),陈旧性心肌梗死及稳定型心绞痛凝血因子Ⅶ活性亦明显升高(P<0.05),全部受检测者凝血因子Ⅶ活性与糖化血红蛋白呈正相关(γ=0.421,P<0.001)。结论血糖可能通过影响凝血功能,促进血栓形成,在2型糖尿病心血管并发症的发生发展中起着重要的作用。
Aim To investigate the correlation between glycosylated hemoglobin A1c（GHbA1c） and Ⅶ factor activity in type 2 diabetic patients with different types of coronary heart disease（CHD）.Methods Concentrations of GHbA1c and plasma activities of Ⅶ were measured in 73 patients with difference types of coronary heart disease and 40 T2 diabetic patients.Results In the patients of actual myocardial infarction and unstable angina pectoris Ⅶ activity was significantly higher than those of diabetic patients（P〈0.05）.In the old myocardial infarction and stable angina pectoris Ⅶ activity was higher than those of normal controls（P〈0.01）.There was a positive correlation between the concentration of GHbA1c and activity of Ⅶ in all the patients and controls.Conclusion Concentration of blood glucose positively correlated with Ⅶ factor.Serum blood glucose may play an important role in the pathogenesis of T2 diabetes mellitus by inducing coagulative and fibrinolytic dysfunction.
出处
《中国动脉硬化杂志》
CAS
CSCD
2007年第6期461-462,共2页
Chinese Journal of Arteriosclerosis
