摘要
目的分析血浆置换和内科综合治疗在治疗慢性乙型重型肝炎中的影响因素,评价血浆置换在治疗慢性乙型重型肝炎的效果。方法比对1997至2004年间收治的422例慢性乙型重型肝炎患者,观察血浆置换治疗和内科综合治疗对其疗效及生化指标改变的影响,同时观察置换的血浆量、置换次数及病程的不同阶段等因素对治疗效果的影响。结果血浆置换治疗效果与患者年龄、性别、血型无关;与肝性脑病、肝肾综合征有关;与腹膜炎、门脉高压症无关;并发症与治疗效果负相关;置换次数与治疗效果正相关。血浆置换治疗与内科综合治疗效果对比尚不能确定谁优谁劣。血浆置换可在病程的不同阶段改善患者部分肝功能和血常规指标,提高临床综合治疗效果。结论选择适当血浆置换量、置换次数及治疗时机有助于提高血浆置换的辅助治疗效果。
Objective To evaluate the value of plasma exchange （PE） therapy for chronic severe hepatitis B （CSHB） by analyzing the influence factor of treatment of CSHB with PE and internal comprehensive therapy. Methods To observe the influence to efficacy and biochemical index with treatment of CSHB with PE and internal comprehensive therapy, at the same time, to observe the influence to efficacy with different plasma quantity,exchange time ,phase of the course of disease by comparing with 422 cases of CSHB from 1997 to 2004. Results The efficacy of PE is not related to age,sex,blood type; it is related to hepatic encephalopathy and hepatorenal syndrome; it is not related to peritonitis and portal hypertention, The efficacy of PE is passively related to complications and positive to times of exchange. It is not certain that the therapy for CSHB with PE is better than internal comprehensive treatment. PE can remedy partly the hepatic function and blood routine index of patients in different course of disease, and improve the efficacy of clinical comprehensive treatment. Condusion It helps to improve the efficacy of PE through choosing appropriate quantity of exchange ,exchange times and auxiliary treatment opportunity.
出处
《临床肝胆病杂志》
CAS
2007年第5期349-351,共3页
Journal of Clinical Hepatology
关键词
乙型肝炎
血浆置换
影响因素
分析
Hepatitis B
plasma exchange
influence factor
analysis
