摘要
作者观察了130例冠心病患者血管活性激素和止凝血14项指标的变化、结果发现，促凝物质Ⅷ：C和ⅧR：Ag增加，AT-Ⅲ：Ag和PC：Ag降低。提示冠心病患者体内存在着高凝倾向和多种促血栓形成因素。在心肌梗塞和不稳定型心绞痛患者体内，Ⅷ：c、ⅧR：Ag、ET和AT－Ⅱ增高更为显著，并伴有血小板聚集功能的增强和ⅧR：Ag／Ⅷ：c比值增高（＞1），与稳定型心绞痛和隐性冠心病患者有显著差异。进一步说明冠心病患者体内高凝状态的存在，同时伴有血管活性激素异常，而且与临床病情相一致．从而提示：二者均为冠心病发病过程中的重要机制。
The hyper-coagulable state and vascular activity hormone in 130 patients with coronary heart disease were studied. The results showed that the level of Ⅷ:C and ⅧR:Ag were increased, while AT-Ⅷ:Ag and PC:Ag were decreased. There was hyper-coagulable state in these patients. The leve1 of Ⅷ:C, ⅧR:Ag, ET and ATll were increased significantly in patients with myocardical infarction and unstable angina pectoris. There was significant difference between these patients and patients with stable angina pectoris or potential coronary heart disease in level of Ⅷ:C,ⅧR:Ag, ET and AT Ⅱ. It suggested that there was also abnormality of vascular activity hormone in patients with coronary heart disease. Hyper-coagulable state and abnormality of vascular activity hormone both contributed to some effects on the pathogenesis of coronary heart disease.
出处
《上海第二医科大学学报》
CSCD
1997年第2期95-97,共3页
Acta Universitatis Medicinalis Secondae Shanghai
关键词
冠心病
血管活性激素
血液凝固性
coronary heart disease
vascular activity hormone
coagulation
