摘要
目的研究2型糖尿病和肾功能不全患者治疗前后的血浆尾加压素Ⅱ(urotensinⅡ,UⅡ)水平的变化。方法采用放射免疫分析法检测血浆UⅡ含量,并进行相关指标检测。结果2型糖尿病肾功能正常组及糖尿病肾病肾功能不全尿毒症组血浆UⅡ水平均明显高于健康人。而糖尿病组和肾功能不全尿毒症组在治疗前后,血浆UⅡ含量无明显变化。肾功能不全组在合并与否糖尿病时血浆UⅡ含量无明显变化(P>0.05)。空腹血糖、血肌酐的水平改变对UⅡ水平并无影响。结论UⅡ可能在2型糖尿病和/或肾功能不全病理生理过程中发挥着十分重要的作用。
Objective To investigate the changes of plasma Urotensin Ⅱ （UⅡ） levels with the treatment in patients with Type 2 diabetes meUitus （T2DM） and renal insuflleieney.Methods Peripheral venous blood was collected in EDTA from normal healthy controls and patients,the blood was then centrifuged and plasma was collected,UⅡ levels in plasmas were measured by radio immuneoassay. Results The mean plasma U Ⅱ level was 5.52 ± 0.93 pg/ml in control group, and was 7.46 ± 1.21 pg/ml ,7.73 ±0.49 pg/ml, 8.47±1.55 pg/ml in patients Group A , Group B and Group C respectively, （P 〈 0.05） . There were no significant differences between plasma U Ⅱ levels be.fore and after the Insulin treatment in Group A, （ P 〉 0.05） . There were no significant differences between plasma UⅡ levels be.fore and after the hemodialysis treatment in Group B and Group C respectively（P〉 0.05）.UII levels were no significant differences among Group A, Group B and Group C （ P 〉 0.05）. Conclusion The plasma U Ⅱ levels were elevated significantly both in T2DM patients and renal insufficiency patients compared with normal controls, but there were no significant differences of the plasma U Ⅱ levels between renal insufficiency patients with and without T2DM. The changes of fasting blood sugar and blood serum creatinine could not affect the U Ⅱ levels. U Ⅱ did not have significant correlations with FBS, Scr.
出处
《中国实验诊断学》
2007年第10期1362-1364,共3页
Chinese Journal of Laboratory Diagnosis
