摘要
通过α-萘乙酸和SOCl2在无水苯中反应制得α-萘乙酰氯,与硫氰酸钾反应生成α-萘乙酰基异硫氰酸酯,再与芳基酰肼进行加成反应,合成8种新型N,N′-萘乙酰基取代芳乙酰胺基硫脲类化合物(Ⅱ1～Ⅱ8)。产物经元素分析、1HNMR和IR测试技术确定。初步的生物活性试验结果表明,目标化合物对稻子根生长具有促进作用,尤以质量浓度为1mg/L时效果最好,但对大肠杆菌和枯草杆菌均无明显抑菌作用。
Eight novel N, N＇-naphthalene acyl substituted aromatic acylamino thiocarbamides （ Ⅱ1 - Ⅱ 8 ） were synthesized from aryl acylhydrazine（ Ⅰ ） and α-naphthalene acyl isothiocyanate, which was obtained by the reaction of potassium thiocyanate with α-naphthalene acyl chloride obtained from 2-naphthylacetic acid and thionyl chloride, in anhydrous benzene. The structures of the products were characterized by IR, ^1 H NMR and elemental analysis. The preliminary biological activity test indicated that the synthesized compounds could promote the growth of paddy root with best effect at 1 mg/L, but had no obvious inhibition activity against B. subtiles and E. coli.
出处
《应用化学》
CAS
CSCD
北大核心
2007年第10期1145-1148,共4页
Chinese Journal of Applied Chemistry
基金
河南省教育厅自然科学研究项目(2003150004)
关键词
萘乙酰基
芳乙酰胺基
硫脲
加成反应
合成
α-naphthalene acyl, substituted aromatic acylamino, thiocarbamide, synthesis, biological activity
